EGF Family - PowerPoint PPT Presentation

egf family egf is the founding member n.
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EGF Family

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  1. EGF Family EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF family members have at least one common structural motif, the EGF domain, which consists of six conserved cysteine residues forming three disulfide bonds. Most are synthesized in membrane- associated pro forms before liberation by proteolytic cleavage. EGF’s other family members include HB-EGF,TGF-α, epigen, neuregulins, amphiregulin, betacellulin, and others. Epidermal growth factor (EGF) stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is a 6-kDa protein with 53 amino acid residues and three intramolecular disulfide bonds. EGF was originally described as a secreted peptide found in the submaxillary glands of mice and in human urine. EGF has since been found in many human tissues including submandibular gland, parotid gland. Initially, human EGF was known as urogastrone.