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Vision for the ICR Program (end of 2017)

Maintain and extend world leadership in FT-ICR MS instrumentation and capabilities: Highest magnetic field ( 21 T (also EMSL)) Highest resolution and mass accuracy New ionization methods Ion optics Automation Data reduction. Vision for the ICR Program (end of 2017).

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Vision for the ICR Program (end of 2017)

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  1. Maintain and extend world leadership in FT-ICR MS instrumentation and capabilities: Highest magnetic field (21 T (also EMSL)) Highest resolution and mass accuracy New ionization methods Ion optics Automation Data reduction Visionfor the ICR Program (end of 2017) Orbitrap --possible 2-3x improvement? Multi-Pass Time-of-Flight--possible 2-3x improvement? as of summer 2010, mid-point in current award period

  2. Future Fuels Institute Joint industrial partnerships to establish a rational molecular-level basis for understanding and predicting the properties and behavior of petroleum (especially heavy ends) and biofuels $250K/year for 4 years initially per Member Company >80% Publishable (Grad Students/Postdocs) <20% Proprietary (Staff--Treat as Patent I.P.) Shell Global Nalco UOP Saudi Aramco ConocoPhillips Total (France) ExxonMobil Sinopec PetroChina Exploratory Biofuels (1-2 year, $50-100K each): Sapphire Energy, Primus, Solazyme

  3. Petroleomics as a Predictive Tool Distillation Hydroprocessing: Chemical Reactivity Modeling Oil/Water Emulsions Asphaltene Cracking Compartmentalization Petroleomics database: >100,000 cpds from 77 Crudes Quantitation: HPLC FT-ICR MS (W. Robbins, ex-ExxonMobil) Distillation: GCxGC 7 T FT-ICR MS (Partner with Zoex) Pilot Data: 2010-2011 SBIR: 2011 Commercial Instrument 2012 Oil Spill Monitoring Nalco, Woods Hole, NSF RAPID $$?, BP $$?

  4. Target needs for FT-ICR MS for Biochemistry & Biology NIH: H/D Exchange to Map Interfaces in Protein Complexes Drug Design Top-Down Proteomics (Human Proteome) Cell Membrane Lipids/Glycolipids Metabolomics Biomarkers Partners: Pfizer (Donated ESI/TOF mass spectrometer) M. D. Anderson Cancer Center Scripps La Jolla Northwestern U. Need Bioinformatics Expert

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