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DIVISION OF BIOMEDICAL SCIENCES. Fundamental Research. Transformative Results . Strategies for Early Stage Investigators National Institutes of Health June 2009 Dr. Lizanne DeStefano I-STEM Education Initiative University of Illinois at Urbana-Champaign. 1110 Micro & Nanotechnology Lab

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slide1

DIVISION OF

BIOMEDICAL SCIENCES

Fundamental Research. Transformative Results.

Strategies forEarly Stage Investigators

National Institutes of Health

June 2009

Dr. Lizanne DeStefano

I-STEM Education InitiativeUniversity of Illinois at Urbana-Champaign

1110 Micro & Nanotechnology Lab

208 N. Wright Street

Urbana,IL 61801

217.244.8480

biomedical@illinois.edu

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Successful NIH Grant Writing

June 24, 2009

GRANT ROLE & STATUS

  • • K Awards
    • Mentored or Independent Scientist
  • • R (R03, R21, R01) Awards
    • - Principal Investigator
    • - Bolster Project Expertise & Experience with:
      • • Co-Investigators - budgeted
      • • Other Significant Collaborators - not budgeted
      • • External Advisory Board – stipends
    • - Possibility of Multiple PIs

DIVISION OF BIOMEDICAL SCIENCES

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Successful NIH Grant Writing

June 24, 2009

NIH FUNDING FOR EXTRAMURAL RESEARCH

  • • Career Development Opportunities:
    • Mentored Research (pre & post-doc, new faculty)
    • Transition to Independent Research
  • • Ongoing Research Opportunities:
    • Investigator-Initiated Research, Unsolicited
    • Program Announcement (PA), Solicited
  • • One-Time Research Opportunities:
    • Request for Applications (RFA), Solicited
    • Request for Proposals (RFP), Solicited

DIVISION OF BIOMEDICAL SCIENCES

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Successful NIH Grant Writing

June 24, 2009

ENTRY-LEVEL K (CAREER) AWARDS

DIVISION OF BIOMEDICAL SCIENCES

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Successful NIH Grant Writing

June 24, 2009

ENTRY-LEVEL RESEARCH CAREER AWARDS

  • • K01: Mentored Research Scientist
  • • K08: Mentored Clinical Scientist
  • • K23: Mentored Patient-Oriented Research Career
  • • K25: (since 2000) Mentored Quantitative Research
    • - Quantitative science and engineering
  • • K99: (since 2008) NIH Pathways to Independence:
    • Includes Mentored + Independent Research
    • Up to 3 Yrs to successful R01.

DIVISION OF BIOMEDICAL SCIENCES

slide6

March 19, 2009

Successful NIH Grant Writing

June 24, 2009

NUMBER OF ENTRY LEVEL RESEARCH CAREER AWARDS

Number of Awards

Fiscal Year

DIVISION OF BIOMEDICAL SCIENCES

slide7

March 19, 2009

Successful NIH Grant Writing

June 24, 2009

SELECT RESEARCH CAREER DEVELOPMENT AWARDS: APPLICATIONS, AWARDS, & SUCCESS RATES

DIVISION OF BIOMEDICAL SCIENCES

slide8

March 19, 2009

Successful NIH Grant Writing

June 24, 2009

K-AWARD FUNDING

• Mentored Awards (K01, K08, K23, K25):

  • Salary: .50 FTE minimum
  • Research Development:
  • Tuition & fees, research expenses, meeting & training travel, statistical

• K22 Career Transition (post-doc to faculty)

  • Salary: .75 FTE minimum, up to $100K/yr + fringe
  • Research Expenses: Up to $50K per year

• K99 Pathways: 1-2 yrs post-doc + up to 3 yrs independent research

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

PURSUING A K AWARD

  • • Seek information from
    • - NIH Office of Extramural Research
  • • Seek advice from
    • - Mentors with existing NIH track records
    • - NIH Institute Personnel

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

RESEARCH GRANTS:

INITIATING AN UNSOLICITED SUBMISSION

Identify specific NIH Research Area & Program

Write one-page sketch

Contact Program Officer with one-pager: discuss ideas, assess fit with program goals

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

RESEARCH GRANTS: PROGRAM ANNOUNCEMENTS (PA)

• Solicit applications in given research area

• New, ongoing or expanded interest &/or high-priority program

• 3-5 year fundingperiods

• Standardized yearly cycle (receipt, peer review, council review, & start)

• Available until PA expires

• Most common form of NIH grant competition

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

RESEARCH MECHANISMS: R03

Small Research Grant (R03)

  • • $50K in direct costs each year for two years
    • - Project can be carried out in a short period with limited resources
      • • Pilot or feasibility studies
      • • Secondary analysis of existing data
      • •Development of research methodology and/or technology

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

RESEARCH MECHANISMS: R21

Exploratory/Developmental Research Grant (R21/R33)

  • • $250K in Direct Costs over 3 Years
    • - Innovation & novelty
    • Pilot-scale support for potentially ground-breaking ideas & methods.
      • Lacks preliminary data to document feasibility
    • - Major impact on biomedical research if successful

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

RESEARCH MECHANISMS: R01

Research Project Grant (R01)

  • • No set $ cap or duration,
  • • Size thresholds – consult announcement & program officer!
    • - Discrete project in investigator's area
    • - Documented preliminary data required
    • - Largest NIH funding category

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

ALLOCATIONS OF R01 GRANTS (FY2003)

Awards Made:

• 82% for investigator-initiated research grants

• 10% for Program Announcements

• 8% for RFAs

For more information on funding rates >>

DIVISION OF BIOMEDICAL SCIENCES

slide16

March 19, 2009

Successful NIH Grant Writing

June 24, 2009

PUBLISHED DATES:

UNSOLICITED & PROGRAM ANNOUNCEMENTS

DIVISION OF BIOMEDICAL SCIENCES

slide17

March 19, 2009

Successful NIH Grant Writing

June 24, 2009

MORE INFORMATION ON THE NIH CYCLE

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

NEW & EARLY STAGE INVESTIGATOR POLICIES

  • • New Investigator:
    • - No Previous NIH R01 research grant funding
    • - No negative effect on status if have:
      • •Small Grant (R03)
      • •Exploratory, Developmental Research Grant (R21)
      • •Loan repayment programs
      • •Fellowships

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

EARLY STAGE INVESTIGATOR (ESI)

  • • An ESI is a New Investigator with
    • - Terminal research degree within past 10 years
    • - Not yet awarded substantial, competing NIH research grant 
  • • How does NIH recognize ESIs?
    • NIH eRA Commons profile data: degree conferral and medical
    • residency dates
    • -Be VERY selective about sharing your eRA Commons login!

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

NIH COMMITMENT TO NEW & EARLY STAGE INVESTIGATORS

  • • Special consideration during peer review & at time of funding
    • - Accelerated feedback schedule
    • - Early opportunities to resubmit
  • • Peer reviewer instructions:
    • - Focus more on proposed approach than on track record
    • - Expect less preliminary data than from established investigator

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

DEFINED, SPECIFIC RESEARCH PURPOSE

• Specific project goals

• Articulate limited set of hypotheses

• Plans for analysis: tie to stated research hypotheses or questions

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

COMPETITIVE PROJECT DESIGN

• Limit size & scale (manageability)

• Provide concrete project design

• Document instrument validity

• Assign specific roles to project personnel

• Provide realistic time & activity sequences

• Plan for revisions & changes needed while project is underway

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

BUDGET DESIGN

  • • What do you NEED to do the work?
  • • Support all research narrative activities
  • • University budget: Work with business staff
    • - Adjust totals to award limits
    • - Meet funder requirements
    • - Meet University requirements

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

SUBMIT… AND RESUBMIT

  • • Submission Outcomes
    • - Anticipate peer reviewer feedback
    • - Respond to all specific points
    • - Build on experience and previous submissions
  • • Resubmissions: As of 1/25/2009, limited to ONCE!

DIVISION OF BIOMEDICAL SCIENCES

slide25

June 24, 2009

Grants Homework

Determine grant mechanism and institute for submission

Find a relevant funding opportunity and review application guidelines

Write specific aims (1-page limit)

Include name and contact information

Save file as:

LAST NAME_Award Type-Institute

6. Submit to kuzmuk@illinois.edu by 12:00 noon on Monday, July 6th

DIVISION OF BIOMEDICAL SCIENCES

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March 19, 2009

Successful NIH Grant Writing

June 24, 2009

PREPARING SPECIFIC AIMS

  • After reading the specific aims, a reviewer should be able to answer the
  • following questions:
    • What is your hypothesis? (Is it focused?)
    • How will you test your hypothesis? (Are your approaches reasonable & appropriate?)
    • Why is the work important to the mission of NIH?
    • What makes your ideas/approach/talents unique?
  • Detailed tutorial on preparing an application >>

DIVISION OF BIOMEDICAL SCIENCES