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Gastrointestinal stromal tumor (GIST). Most common mesenchymal neoplasm of the gastrointestinal tractStill rareAnnual incidence estimates 6.8 to 14.5/million40% high risk or malignant features1,500-4,000 cases per year Osteosarcoma 660 new cases per yearExtremely rare in childrenResistant to

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