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Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors - PowerPoint PPT Presentation


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Background. Antidepressant treatment induces histone acetylation ? transcriptional activationStress increases DNA methylation ? transcriptional repressionRepression ? depressive-like behavior. Goal. Examine effects of DNA methyltransferase (DNMT) inhibitors Systemic and Intra-hippocampal admini

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