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Immunogenetics and Applications in Immunology Recognition

This comprehensive guide delves into the field of immunogenetics, exploring methods to recognize individual differences and study immunological phenomena. Learn about key figures like Edward Jenner and Karl Landsteiner, as well as fundamental concepts such as transplantation antigens and MHC molecules.

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Immunogenetics and Applications in Immunology Recognition

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  1. IMUNOGENETICS prof. Ing. Karel Hála, CSc. Universität Insbruck Rakousko

  2. Immunogenetics- application of methods of immunology to the recognition of individual differences(e.g. blood groups, protein allotypes, transp. antigens)- application of genetic methods to the study of immunological phenomena(e.g. mechanisms determining antibody induction, disease resistance, autoimmunity) • Edward Jenner - 1796 (cowpox - protection against human smallpox) • Gregor J. Mendel - 1865 • Karl Landsteiner - 1900 (ABO blood group) • M.R. Irwin - 1947 (Streptopelia chinensis, S. risoria) • George Snell - 1948 (kongenní kmeny myší)

  3. Transplantation antigensAutograft, syngeneic graft, allograftFirst-set rejection, second-set-rejection

  4. The expression of MHC molecules differs between tissues

  5. HLA genes are highly polymorphic

  6. MHC class I Molecule MHC class II molecules

  7. Buněčné elementy v kostní dřeni, v krvi a v tkáních

  8. Přehledy vazebných motivů peptidů pro interakci s MHC gp1

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