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VogelsteinScience15Apr13 Updated: April 15, 2013

Why Is Cancer Therapy Such a Difficult and Often Intractable Effort?. Cancer Genome Landscapes. Science, Vol. 339, March 29, 2013, pp 1546 – 1548 Bert Vogelstein, Nickolas Papadopoulos, Victor Velculescu, Shibin Zhou, Luis Diaz, Kenneth W. Kinzler

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VogelsteinScience15Apr13 Updated: April 15, 2013

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  1. Why Is Cancer Therapy Such a Difficult and Often Intractable Effort? Cancer Genome Landscapes. Science, Vol. 339, March 29, 2013, pp 1546 – 1548 Bert Vogelstein, Nickolas Papadopoulos, Victor Velculescu, Shibin Zhou, Luis Diaz, Kenneth W. Kinzler Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore VogelsteinScience15Apr13.ppt Updated: April 15, 2013

  2. Number of somatic mutations associated with cancers in patients

  3. From 5 or 10 to 130 to 700 mutations per tumor

  4. (Insertions & deletions) (Single base substitutions)

  5. Signaling Pathways Affected In Cancers

  6. Pathway Anomalies in Progression in Colo-Rectal Cancer

  7. The RAS Pathway as a representative signaling pathway affected by cancer mutations and approaches to therapy based on RAS pathway anomalies RTK = receptor tyrosine kinase

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