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Unraveling Cancer Therapy Challenges: Insights from Genome Landscapes

Delve into the complexity of cancer therapy efforts through the lens of cancer genome landscapes, exploring the staggering number of somatic mutations in tumors and the impacts on signaling pathways. Gain a deeper understanding of the RAS pathway anomalies in colorectal cancer progression and innovative therapy approaches.

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Unraveling Cancer Therapy Challenges: Insights from Genome Landscapes

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  1. Why Is Cancer Therapy Such a Difficult and Often Intractable Effort? Cancer Genome Landscapes. Science, Vol. 339, March 29, 2013, pp 1546 – 1548 Bert Vogelstein, Nickolas Papadopoulos, Victor Velculescu, Shibin Zhou, Luis Diaz, Kenneth W. Kinzler Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore VogelsteinScience15Apr13.ppt Updated: April 15, 2013

  2. Number of somatic mutations associated with cancers in patients

  3. From 5 or 10 to 130 to 700 mutations per tumor

  4. (Insertions & deletions) (Single base substitutions)

  5. Signaling Pathways Affected In Cancers

  6. Pathway Anomalies in Progression in Colo-Rectal Cancer

  7. The RAS Pathway as a representative signaling pathway affected by cancer mutations and approaches to therapy based on RAS pathway anomalies RTK = receptor tyrosine kinase

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