The world’s leading provider of innovative rapid-curing assembly solutions

1. The world’s leading provider of innovative rapid-curing assembly solutions

2. Agenda • Brief Dymax Review • Chemistry Basics • Advantages of Light Cure • Typical Medical Applications • Design Considerations • New Technology • Medical Selector Guide Review

3. DYMAX Corporation DYMAX is uniquely positioned as a: • Formulator of Light Curing Adhesives • Designer of Light Curing and Dispensing Equipment

4. The DYMAX EDGE Total solutions from DYMAX increase the efficiency of any manufacturing process.

5. Substrate Selection Adhesive Recommendation Design Consultation Automation Questions Dispensing Curing Recommendations QC Inspection Options Dymax Assists with…

6. Contacts • Jorge Lopez- Alenica • jo_lopez@alenica.com • Fabio Tarazona- Alenica • f_tarazona@alenica.com • Mario Chinchilla- Alenica • mchinchilla@alenica.com • John Kyger – Regional Sales Manager, Dymax • jkyger@dymax.com

7. Dymax Chemistries • Acrylated Urethanes (standard light curing materials) • Activator-Cured Acrylics • UV Epoxies • Moisture-Cure Materials (Dual-Cure) • Cyanoacrylates • Two-Part Epoxies • Heat-Curable Epoxies

8. Advantages of Light Curing Adhesives Cure in seconds ‘On Demand’ Cure with UV and Visible Light 100% solids, no volatiles or solvents Single part Gap filling Non flammable Non-toxic when fully cured and passes USP Class VI & ISO 10993 Typically 1 year shelf life at room temperature

9. Markets Served

10. Typical Medical Applications Single-use Devices: • Needles/ Syringes • Catheters • Airway ManagementDevices • Reservoirs • IV- Tube-Sets • Oxygenators • Blood-Pumps

11. Design Considerations • Substrates • Bond gaps • 0.002-0.006 inch gap preferred, typical • 0.001-0.003 inch gap preferred, needle/hub • UV Curing Systems • Required Approvals

12. Typical Substrates • PVC - strong bonds achievable. Caution with highly plasticized PVC • PC, PS, ABS, PUR - strong bonds achievable • TPE, SEBS, Pebax - selective adhesives • Silicone - requires surface treatment

13. Bond Gaps • 0.001-0.003 inch gap preferred, needle/hub 0.002”- 0.006” gap preferred for best adhesive strength

14. UV Curing Considerations • Oxygen Inhibition - The phenomenon where some adhesives have a wet film on the surface after cure • Oxygen interferes/slows down the cure on the outermost surface of the adhesive leaving the surface semi/uncured. • Techniques to overcome: • Higher intensity and/or longer UV exposure • Remove oxygen from bond line • Interfacial bond • Inert gas blanket (nitrogen) • Try a new adhesive

15. UV Curing Considerations cont. • Pulse curing • Not recommended for Dymax adhesives • Typically results in a tacky surface or not optimal cured properties • LED vs. Broad spectrum (UVA/BlueVis output) • Identify LED wavelength output – UVA or VIS? • Match output of the UV equipment with absorption of the adhesive

16. Required Approvals • Devices are FDA approved, not our adhesives • ISO testing

17. Dymax Adhesive Biocompatibility Tests ISO 10993-4: Selection of tests for interactions with blood (Hemolysis) ISO 10993-5: Tests for in vitro cytotoxicity (Cytotoxicity) ISO 10993-6: Tests for local effects after implantation (Muscle Implantation) ISO 10993-10: Tests for irritation and delayed-type hypersensitivity (Intracutaneous injection) ISO 10993-11: Tests for systemic toxicity (Systemic injection)

18. Sterilization Compatible with sterilization radiation (gamma or e-beam) chemical (ETO or other chemical sterrilants) autoclave (limited to 10-15 cycles max with correct adhesive, substrate and design)

19. New Technology • LED curing adhesives & equipment • Matching output with absorption • Ultra Red™ Fluorescing • Bond-line inspection • See Cure™ • Confirming complete cure

20. New LED Adhesive Technology! • Introducing: • 1120-M-UR • Plastic-to-Plastic Bonder Fully exploits the benefits of LED-Cure! • Lightening-fast, cooler cure • Tack-free surface • Ultra Red fluorescing • BlueWave LED Prime UVA

21. Inspection - Blue fluorescence Adhesive emits blue light at 435-465 nm upon absorption of 365-375 nm black light Detection used for QC bond line inspection automatically manually

22. Ultra-Red™ Ultra Red™ Fluorescing technology allows for faster, deeper depth of cure. www.ultraredadhesives.com

23. Ultra-Red™ Ultra-Red™ Fluorescing Technology Enables Accurate Bond-Line Inspection and Product Verification

24. Ultra-Red™ When do you utilize Ultra-Red? When the plastics fluoresce blue! • Enhances ease of bond line inspection against blue fluorescing plastics

25. Fluorescing Emission Spectrum

26. New Technology: We answered 2 big questions: How do I know that I’ve dispensed a sufficient amount of adhesive in the prescribed area? How do I know when it is cured?

27. See-Cure™ A revolutionary new technology from DYMAX greatly enhances adhesive dispensing and in-line inspection processes for medical device manufacturing companies.

28. See-Cure™

29. Safety Margin See-Cure™ Color Development Cure Color

30. New See-CureTM Adhesive Dymax 211-CTH-SC • Color Change Technology • LED-Curable (very fast) • Plastic bonding • Catheter Assembly • 100 mPa, Shore D70

31. Thank you!..any questions?