Hepatitis Viruses. HAV, HBV NonA-NonB : HCV, HDV, HEV. HAV. Disease Hepatitis A Important properties Typical enterovirus (enterovirus72) classified in Picornavirus Single-stranded RNA genome Non- enveloped icosahedral nucleocapsid Replicates in the cytoplasm of the cell.
NonA-NonB: HCV, HDV, HEV
Typical enterovirus (enterovirus72) classified in Picornavirus
Single-stranded RNA genome
Non- enveloped icosahedralnucleocapsid
Replicates in the cytoplasm of the cell.
Humans and chimpanzees are the only natural hosts.
Genome replication occurs by synthesis of a complementary negative strand which then serves as the template for the positive strands which are needed both for replication and protein synthesis.
Clinical manifestations of hepatitis are virtually the same
Treatment & Prevention
No antiviral therapy.
vaccine is available.
Immune prophylaxy is available
Resolves itselfe spontaneously.
HBsAg (important both in diagnosis and immunization).
DNA-dependent DNA polymerase
A group-specific antigen, ‘a’ and 2 sets of exclusive epitopes, d or y and w or r leading to 4 serotypes: adw, adr, ayw, ayr which are useful in epidemiologic studies.
Humans are the only natural host of HBV.
HBsAg during the incubation period and mostly during the prodome and acute disease.
Prolonged presence of HBsAg indicates carrier state and the risk of chronic hepatitis.
Windows phase: no HBsAg and HBsAb but HBcAb
HbeAg: During incubation period and is present during prodrome and early acute disease (an indicator of transmissibility).
HBeAb indicates low transmissibility.
DNA polymerase during incubation and early in the disease but assay not available in clinical lab.
No one with a history of hepatitis (of any type) should donate blood.