The Sunshine Vitamin in Health and Disease. © BioSoft Publishing 2009. Oh, thou life giving celestial body, welcome to the new day – Anonymous . UV rays and their biological action on skin cells. UVB causes sunburns (longer exposure)
© BioSoft Publishing 2009
UVB causes sunburns (longer exposure)
UVA produces tanning without burning. Longer exposure causes sunburns.
An overexposure to UV radiation (typical summer day) can cause sunburn and in the long run some form of skin cancer.
The most deadly form – malignant melanoma is mostly caused by indirect DNA damage, through oxidative stress due to reactive oxygen species.
UVB can damage DNA directly by causing the formation of a cyclobutane thymine dimer involving two adjacent thymine bases. A bulge appears in one of the strands and as a result DNA replication is impaired.
isomerization reaction because melanin can also absorb UVB radiation.
It has been shown recently that human macrophages treated with a mycobacterium lipoprotein showedincreasedexpression of 25OH D-1alpha hydroxylase and vitamin D receptor as well as the induction of cathelicidin (a class of antimicrobial peptides called defensins) in response to 25(OH) vitamin D3 .
By binding to its nuclear receptor (VDR) vitamin D3 alters the gene expression that regulates cell-cycle arrest, apoptosis and differentiation. Augmented levels of circulating 25(OH)D3 lead to increased synthesis of 1,25()H)2 D3 in extrarenal cells and that helps control growth and maturation, thus decreasing the risk of malignancy. It appears that a 25(OH)D3 blood plasma concentration of at least 20 ng /ml may reduce the risk of developing colon, prostate and breast cancer by 30 to 50%.
The interplay between the enzymes that synthesize and inactivate 1,25(OH)2D3 , respectively
There is a clear need to:
Research carried out in the 1980s and 1990s has indicated that:
There has been growing evidence in the past 20 years or so that micronutrient inadequacy may adversely affect brain function. If a causal relationship between micronutrient deficiencies and the underperforming brain could be demonstrated, that would have major public health implications in terms of enormous savings in medical treatment and care. In the next few slides some of the evidence suggesting such a causal relationship with regard to vitamin D involvement in brain development and cognitive/behavioral function will be presented.
Pro-inflammatory cytokine-induced cognitive/behavioral dysfunction and the possible role of vitamin D3 (calcitriol)
Relationship between vitamin D, pro-inflammatory cytokines and cognitive dysfunction
Good nutrition enhances the quality of life and helps you prevent disease.
The best source of quality micronutrients is in fresh fruit and vegetables. Don’t forget: five servings per day!
DNA and proteins can “sing” and that’s part of the metabolic symphony that cells play nonstop. As you can hear there is harmony in the melody that super-oxide dismutase is singing!
An exciting and provocative book by Bruce Lipton (The Biology of Belief – Hay House, 2008) will certainly challenge the way we look at ourselves and the world around us. Dr. Lipton discusses The Four Myth perceptions of the Apocalypse on YouTube: