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Understanding HIV Integration Patterns for Gene Therapy Applications

This presentation discusses the integration patterns of the HIV virus within the human genome, aiming to explore its potential as a gene therapy delivery vector. Led by Dr. Beverly Davidson, the focus includes various sub-projects like tissue specificity and the number of integrands per cell, building on the foundation of retroviral replication. This research highlights the interest in alternative vectors for effective gene therapy, providing insights into the opportunities and challenges of utilizing HIV for therapeutic purposes.

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Understanding HIV Integration Patterns for Gene Therapy Applications

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Presentation Transcript

  1. Mapping HIV integration October 3, 2002

  2. Introduction GOAL: To infer the pattern of integration of the HIV virus within the human genome. Potential use as a delivery vector for gene therapy. SCID - Andy’s JC Chris’s presentation

  3. Why we are interested Dr. Beverly Davidson – gene vector core Working on alternative vectors for gene therapy. Many sub-projects: • Tissue specificity • Number of integrands per cell

  4. Background Retroviral replication

  5. Why we are interested

  6. Why we are interested

  7. Why we are interested

  8. Why we are interested

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