Viruses of Humans. DNA VIRUSES. Parvoviridae Densivirinae Parvovirinae (Invertebrates) Bocavirus Parvovirus Dependoviruses (AAV) - Erythrovirus - Feline PV Helpers are * B19 parvovirus
- Feline PV Helpers are * B19 parvovirus
- Canine PV - adenoviruses * Semian PV
- Porcine PV - Herpesviruses
- Vaccinia virus
(240 hexons and 12 pentons). Of the hexons 60 are peripentons.
- ds DNA of 34-45 Kbp with a molecular weight
of 20-25 x 106 Daltons.
- A terminal protein (55kd) covalently attached
to the 5-end (TP).
proteins producedin the early phase.
(EBV, HHV-6, HHV-7)
- Host cell range.
- Efficiency and speed of replication.
- Site of latency.
- Clinical manifestations of diseases they cause.
- DNA sequence homology.
- Similarities in genome sequence rearrangement.
- Relatedness of viral proteins.
- A variable host range
- Relative short reproductive cycle
- Rapid spread in culture
- Efficient destruction of infected cells
- Capacity to establish latency primarily but not
exclusively in sensory ganglia
- Restricted host range
- Long reproductive cycle
- Slow progress of infection in culture
- Enlargement of infected cells (cytomegalia)
- Latency in secretary glands, lymphoreticular
cells, kidneys and other tissues.
- Limited host range.
- Replication In vitro in lymphoblastoid cells
- Cause lytic infections in some types of
epitheloid cells and fibroblasts
- Specificity for either T or B lymphocytes
- Latent virus is frequently demonstrated in
- Alpha (immediate early)
- Beta (early)
- Gamma (late)
- Chromatin changes
- Cell membrane alterations
RNA transcripts in lieu of proteins, may be involved in HSV latency (latency associated-transcripts- LATs).
- Most abundant in VZV-infected cells.
- Binds to the FC of IgG
- Induces antibodies that have neutralizing activity in the presence of complement
neutralizing antibodies in the presence of complement
- A size of 172 kbp
- A single over all format and gene rearrangement.
- Reiterated 0.5 Kbp terminal repeats.
- Reiterated 3 Kbp internal repeats, that divide the
genome into short and long unique sequences
- salivary gland tropism
- slow replication in cultured cells.
- Virion penetration into cells
- Transmission from cell to cell
- Fusion of infected cells.
- a prominent target for neutralizing antibodies
- Target for complement-independent neutralizing
- Cell-to-cell transmission of virus
- Membrane fusion.
- Essential for viral replication (entry).
- An abundant envelope glycoprotein
- Target for complement dependent
-A large complex virion containing transcriptase and polymerase.
- A genome composed of a single linear ds DNA of 130-260 Kbp with a hairpin loop at each end (fused).
- A cytoplasmic site of replication.