Den 3. stressforsknings konference 2006. Mind and cancer Christoffer Johansen, M.D., Ph.D., DrMedSci. Head, Department of Psychosocial Cancer Research Institute of Cancer Epidemiology Danish Cancer Society. Background.
Mind and cancer
Christoffer Johansen, M.D., Ph.D., DrMedSci.
Head, Department of Psychosocial Cancer Research
Institute of Cancer Epidemiology
Danish Cancer Society
Major life events
Screening for fam. BC
Current research activities
The central paradigm
by ’mind’ factor
Johansen C. & Olsen JH. No effect of psychological stress on cancer incidence or mortality from nonmalignant diseases.
British Journal of Cancer 1997; 75: 144-148
Didier Bar - the Loreto Village with the Vesuvio in eruption, Rome, private collection
Initiator establish gene defect
rate of malignant
When is the vulnerable exposure window (?)
S Oksbjerg Dalton, L Mellemkjær,
JH Olsen and C Johansen, ,PB Mortensen. Depression and cancer risk: A register-based study of patients hospitalized with affective disorders, Denmark, 1969-93
American Journal of Epidemiology2002; 155: 1088-95
This study gives no further support to the hypotheses that depression increases the risk for cancer
The increased risk observed in this study can
probably be ascribed to increased smoking
Schapiro I, Falgaard Nielsen L, Jørgensen T, Boesen E, Johansen C. Psychic vulnerability and the associated risk of cancer.
Cancer 2002; 94: 3299-3306
A number of studies have reported that personality influence the risk of cancer
Hagnell 1966, Huggan 1968, Abse et al. 1974, Dattore et al.1980, Kirkcaldy & Kobylinska 1987, Scherg 1987, Grossarth-Maticek et al. 1988, Quander-Blaznik 1991
A reaction readiness defined by a low threshold of being influenced and a risk of inexpedient reactions in social interaction or in a psychosomatic direction
Stress does not cause cancer
The agent (mixture) is probably not carcinogenic to humans
Policies to prevent smoking and alcohol consumption may focus more on well defined groups at risk for developing these behaviours