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U.S. Department of Health and Human Services

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U.S. Department of Health and Human Services

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    2. Primary Objective ALLHAT - LLT

    4. Secondary Outcomes CHD Cause-specific mortality Total and site-specific cancers

    5. Major Subgroups (a priori) Age 65+ Women African-Americans Type 2 Diabetes

    6. Major Subgroups (post hoc) CHD at Baseline No CHD and LDL-C = 130 mg/dL No CHD and LDL-C < 130 mg/dL

    7. Eligibility Criteria

    9. Exclusion Criteria Continuing use of prescribed lipid-lowering agents Contraindications to statins Secondary cause of elevated serum cholesterol ALT > 2 times ULN

    10. Clinical Sites in LLT 513 clinical sites United States, Canada, Puerto Rico, US Virgin Islands VA, private & group general medicine practices, community health centers, HMOs, specialty practices Variety of research experience

    12. Vital Status at Closeout 8776 (84.8%) known alive 1272 (12.3%) confirmed deaths 55 ( 0.5%) confirmation of death pending 206 ( 2.0%) lost 46 ( 0.4%) refused

    27. Meta-Analysis of Large Long-Term Statin Trials and Impact of ALLHAT - LLT

    30. Conclusions ALLHAT - LLT

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