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CDK4
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GF. +. CDK4AK?. +. p. p21. (S807/811). p. p (S780). pRb. ?. +. cyc D1. +. DNA replication. cyc D1. cyc D1. cyc D1. p21. p21. CDK4. CDK4. CDK4. p. pRb. CDK4. active. nucleus. DEDIFFERENTIATION. insulin/IGF. TSH (cAMP). CDK4AK?. +. +. p27. p. p. p (S780). pRb.
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CDK4
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GF + CDK4AK? + p p21 (S807/811) p p(S780) pRb ? + cyc D1 + DNA replication cyc D1 cyc D1 cyc D1 p21 p21 CDK4 CDK4 CDK4 p pRb CDK4 active nucleus DEDIFFERENTIATION insulin/IGF TSH (cAMP) CDK4AK? + + p27 p p p (S780) pRb + + cyc D3 + DNA replication cyc D3 cyc D3 cyc D3 p27 p27 CDK4 CDK4 CDK4 p - - pRb CDK4 active nucleus DIFFERENTIATION TGFb
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