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Life course model of cognitive reserve

Life course model of cognitive reserve. Advanced Psychometrics Methods Web Conference – 2/16/10. Workgroup Members. Angela Jefferson (AJ) angelaj@bu.edu Laura Gibbons (LEG) gibbonsl@u.washington.edu Dorene Rentz (DR) drentz@partners.org Janessa Carvalho (JC) jocarval@psych.umass.edu

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Life course model of cognitive reserve

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  1. Life course model of cognitive reserve Advanced Psychometrics Methods Web Conference – 2/16/10

  2. Workgroup Members • Angela Jefferson (AJ) angelaj@bu.edu • Laura Gibbons (LEG) gibbonsl@u.washington.edu • Dorene Rentz (DR) drentz@partners.org • Janessa Carvalho (JC) jocarval@psych.umass.edu • Jennifer Manly (JM) jjm71@columbia.edu • Yaakov Stern (YS) ys11@columbia.edu • David Bennett (DB) dbennett@rush.edu • Rich Jones (RNJ) jones@hrca.harvard.edu

  3. MAP Life Course Factors • Cognitive Activities Scale (CAS) • Early-life activities (ZCAE) • Mid-life activities (ZCA40) • Late-life activities (ZCA99) • Socioeconomic Status (SES) • Early childhood SES (ZSESEARLY) • Adult SES (ZSESNOED) • Education Level (ZEDUC) • Late life reading ability - NART (ZSCREAD)

  4. MAP Cognitive Protocol

  5. Basic model for all cognitive outcomes

  6. Results – total MAP sample

  7. Results –MAP sample excluding “possible” dementia

  8. Results –MAP sample including ONLY “possible” dementia

  9. Life Course Factors – Preliminary Conclusions • Global Cognition & Visuospatial Abilities • Education exerts greatest influence • Episodic Memory & Semantic Memory • Education exerts greatest influence (except for in MCI/early cognitive decline, in which late life cognitive activities have greatest influence) • Working Memory • NART exerts greatest influence • Perceptual Speed • Late life cognitive activities has greatest influence

  10. Life Course Factors – Project Status • Statistical Analyses • “work in progress” • Manuscript Development • Target completion late March 2010 • Recent Abstract Submission • ICAD 2010 (Hawaii) – submitted 2/01/10 • Possible Future Manuscript Development • Examine life course factors in relation to neuropathological markers

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