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2. Tools and processes for producing and creating user-welcoming website interfaces to receive far more income era. Pandemi Covid-19 yang melanda di hampir seluruh penjuru dunia, termasuk Indonesia, membuat kebijakan pembatasan sosial dan fisik diberlakukan untuk mengurangi penyebaran virus ini. Akibat dari dilakukannya isolasi sosial salah satunya adalah terjadi penurunan kondisi psikologis, yaitu depresi yang diakibatkan oleh kecemasan akan penyakit, rutinitas yang terganggu, dan kurangnya kontak sosial. Situasi yang tidak biasa membutuhkan trait positif optimisme karena individu yang optimis mengharapkan hasil akhir yang baik dalam setiap situasi. Oleh karena itu, penelitian ini bertujuan untuk mengetahui sejauh mana optimisme mampu menjadi mediator hubungan isolasi sosial dengan depresi pada masa pandemi Covid-19. Jenis penelitian ini kuantitatif dengan teknik analisis mediator. In scarce instances, neocentromeres can variety at new web-sites with a chromosome due to a repositioning on the centromere. This phenomenon is most popular from human scientific scientific tests and you will find at the moment about 90 identified human neocentromeres discovered on 20 various chromosomes.[35][36] The development of the neocentromere has to be coupled Using the inactivation of the prior centromere, since chromosomes with two purposeful centromeres (Dicentric chromosome) will lead to chromosome breakage all through mitosis. In certain uncommon scenarios human neocentromeres have already been observed to variety spontaneously on fragmented chromosomes.