Introduction

1. Cystic FibrosisTia MartinRita RipleyDebbie FieldsHeather DoroughKyle KopytkoUniversity of PhoenixJune 28, 2009

2. Introduction

3. History of CF

4. Causes and Treatments

5. Data on affected population • 30,000 people in the US have CF • 1,000 are babies • Life expectancy 30s • Approximately one in 31 people are carriers of the CF gene http://www.netterimages.com/images/vpv/000/000/000/131-0550x0475.jpg

6. Data on affected population • Infants show early signs • Symptoms: diarrhea, greasy stools, persistent cough, poor growth http://graphics8.nytimes.com/images/2007/08/01/health/adam/18135.jpg

7. Data on affected population

8. Economic Impact Cysticfibrosis is the most common life-shortening genetic disorder among white individuals worldwide. Estimatesof the costs of medical care have been based on expert opinionrather than observed costs. • The annual cost of medical care in 2009 averaged $18,300 and ranged from $9200 among patients with mild disease to $83,300among patients with severe disease. • Of total costs: • 47% were fromhospitalization • 18% were from DNase (Pulmozyme) • 12% were fromclinic visits • 10% were from outpatient antibiotics. • Whenthe observed costs were used to estimate the costs of medicalcare for the entire population of CF patients in the United States,these costs were estimated to be about $814 million per year in 2009. • (Cystic Fibrosis Foundation, 2009)

9. United States Budget for Cystic Fibrosis

10. Prevention in the Community • Keep children’s immunizations up to date • No SMOKING and avoid secondhand smoke • Use airway clearance techniques • Eat nutritious meals that are high in calories • Have regular checkups • Seek care from specialized CF centers

11. Education Resources • Books and Other Written Materials- “Spirit of Lo” An Ordinary Family’s Extraordinary Journey….life’s dance on the edge of mortality by Terry & Don Detrich An Introduction to Cystic Fibrosis for Patients and Families by James C. Cunningham, M.D. and Lynn M. Taussig, M.D. “Now That I Have CF” Information for Men and Women Diagnosed as Adults by the editors of Cystic Fibrosis Australia, national CF site

12. Online Education Resources • www.healingwell.com • www.CysticFibrosis.com • www.cellscience.com

13. Conclusion • Gene therapy • Allele-specific therapies • Pharmaceutical approaches http://www.discovery-diagnostics.com/Nanoduct_Neonatal_Sweat_Analysis.asp

14. References Detrich, Terry, & Detrich, Don (2003). The Spirit of Lo: An ordinary family’s extraordinary journey (1sted), Tulsa, Oklahoma, Mind Matters. Cunningham, James C., Taussig, Lynn M (2003). An introduction to cystic fibrosis for patientsand families (5thed), Bethesda, MD: Cystic Fibrosis Foundation, Birmingham, AL: Axcan Scandipharm Inc. Palys, B, Palys, J.R., Widerman, E. (2003), “Now that I have CF” Information for men and women diagnosed as adults,Western Australia, Solvay Pharmecueticals. Alma, L. (2008). Treating Cystic Fibrosis. About.Com. Retrieved June 20, 2009, from http://cycticfibrosis.about.com/od/treatment/a/CFtreatment.htm. Hamann, B. (2007). Disease: Identification, Prevention and Control. McGraw-Hill. Retrieved June 20, 2009, from The University of Phoenix, rEsource, Introduction to Health and Disease Trends. Littlewood, J. (2202). The History of the Development of Cystic Fibrosis Care. The UK CF Trust. Retrieved June, 23, 2009, from http://www.cystic fibrosismedicine.com/htm/docs/CFText/historyof.htm. North, S. (2008). Cystic Fibrosis: A Brief History of the Disease in the United States. Associated Content. Retrieved June 23, 2009, from http://www.associatedcontent.com/article/516097/Cystic_fibrosis_a_brief_hisotry_of.htm?cat=37. Cystic Fibrosis Foundation, 2009. Economic Impact. Retrieved: June 19, 2009. Website: http://www.cff.org Images-http://www.discovery-diagnostics.com/Nanoduct_Neonatal_Sweat_Analysis.asp Davis, Pamela B., 2005, Cystic Fibrosis Since 1938, Centennial Review, American Journal of Respiratory and Critical Care Medicine, Vol 173