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Testes Cancer. Dr. Kenneth Lim Urology – MSU-COM POH McLaren Medical Center. Testes Cancer. Most common solid tumor in 20s High cure rate Delay in diagnosis due to fear, ignorance, failure for self examination Presentation – painless testicular mass. Testes Cancer -Treatment.

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testes cancer

Testes Cancer

Dr. Kenneth Lim

Urology – MSU-COM

POH McLaren Medical Center

testes cancer1
Testes Cancer
  • Most common solid tumor in 20s
  • High cure rate
  • Delay in diagnosis due to fear, ignorance, failure for self examination
  • Presentation – painless testicular mass
testes cancer treatment
Testes Cancer -Treatment
  • Cure milestones – 2 and 5 years
  • Surveillance protocols – reliabilty
  • Serum markers – use to justify treatment
  • Surgery(RPLND) – diagnostic and therapeutic
  • Chemotherapy – must weigh therapeutic advantage vs. salvage cure rate
testes ca
Testes Ca
  • 1% -Benign
  • Non-Germ Cell (5-10%)
    • Leydig cell
    • Sertoli cell
  • Germ Cell (90-95%)
    • Seminoma
    • Non-seminoma
testes ca epidemiology
Age

0-10

20-30

25-35

30-40

>50

Histology

Yolk sac tumor

Choriocarcinoma

Mixed – E,T, TC

Seminoma

Lymphoma

Testes Ca - Epidemiology
risk factors for testes ca
Risk factors for Testes Ca
  • Cryptorchidism
  • HIV infections
  • Intratubular Germ Cell Neoplasia
  • Gonadal dysgenesis with Y chromosome
staging
Staging
  • Tumor markers
    • AFP, HCG, LDH
  • Chest, Abdominal, Pelvic CT Scan
  • Brain Scan
testes ca 5 year survival
Stage Risk Status

I -

IIA / IIB -

Good

IIC / III Intemed

Poor

Seminoma Nonsem

>98 >98

>95 >95

86 92

72 80

48

Testes Ca 5 Year Survival
surgery for testes ca
Surgery for Testes Ca
  • Radical Orchiectomy
  • Retroperitoneal Lymph Node Dissection (RPLND)
radiation therapy
Radiation Therapy
  • Retroperitoneal Templates
testes ca chemotherapy for nsgct
Testes Ca – Chemotherapy for NSGCT
  • Bleomycin
  • Etoposide
  • Cisplatin
ad