Can we fix it! Yes we can! Synthesis of Novel Quorum Sensing molecules Department of Chemistry and Biochemistry
Bacteria • What are bacteria? • How do bacteria communicate with one another? • Quorum sensing
Research Questions By making new signaling molecules which resemble the bacterial signaling molecule: • Will we be able to interfere with the bacterial communication? • Will a damaging agent attach to the signaling molecules so that the bacteria cells will be killed?
Goal • To make several similar compounds with a variation in “R” group
Methods • Overall Scheme:
Why is this project important? • Would benefit the medical, sewage, and marine environment • Would offer a new approach in fighting infections
References • Bassler Bonnie: How bacteria talk to each other: regulation of gene expression by quorum sensing, Microbiology 1999, 2:582-587. • Brelles-Marino G; Bedmar E.; Journal of Biotechnology 91 2001, 197-209 • March J, Bentley W: Quorum sensing and bacterial cross-talk in biotechnology. Biotechnology 2004,15:495-502.