How Pregabalin treat epilepsy and anxiety Whatsapp/skype: 86 186 2712 6189

1. Wuhan wingroup Pharmaceutical Co.,Ltd., http://www.whwingroup.com/ How Pregabalin treat epilepsy and anxiety 1.What is Pregabalin CAS 148553-50-8（ sal e11@ w hw i ngroup. com （raw material） ） Pregabalin, the chemical name (S)-3-aminomethyl-5-methylhexanoic acid, is a white or almost white crystalline powder, and its molecular formula is C8H17NO2. It is an anti-epileptic drug. The main treatment for neuralgia after herpes zoster. sal e11@ w hw i ngroup. com Pregabalin（Lyrica）is a 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation. Pregabalin is a non-gamma-aminobutyric acid (GABA) receptor agonist or antagonist. It is a new type of calcium channel modulator that can block voltage-dependent calcium channels and reduce the release of neurotransmitters. Clinically used for diabetic Chemicalbook peripheral neuropathy related neuralgia, postherpetic neuralgia and adjuvant treatment of adult partial epilepsy, generalized anxiety disorder, central neuralgia (including spinal cord injury, stroke and neuralgia accompanied by multiple sclerosis) And fibromyalgia. 2.Pregabalin CAS 148553-50-8 Interactions Since pregabalin is predominantly excreted unchanged in the urine, undergoes negligible metabolism in humans, does not inhibit drug metabolism in vitro, and is not bound to plasma proteins, it is unlikely to produce or be subject to pharmacokinetic interactions. 1 Sale11@whwingroup.com

2. Wuhan wingroup Pharmaceutical Co.,Ltd., http://www.whwingroup.com/ sal e11@ w hw i ngroup. com sal e11@ w hw i ngroup. com Pregabalin may potentiate the effects of lorazepam. In the post- marketing experience, there are reports of respiratory failure and coma in patients taking pregabalin and other central nervous system depressant medicinal products. Pregabalin appears to be additive in the impairment of cognitive and gross motor function caused by oxycodone.With alcohol/food There are no specific foods that must be excluded from diet when taking pregabalin. Pregabalin may potentiate the effects of alcohol. 3.Pharmacological actionof Pregabalin Pregabalin has a high affinity for α2-δ sites (a voltage-gated calcium channel auxiliary subunit) in central nervous system tissues, although the mechanism of action of pregabalin is not fully understood. However, the modified mouse test results and the test results of compounds similar in structure to pregabalin (such as gabapentin) showed that pregabalin binds to α2-δ sites and inhibits pain and anti-seizures in animal models of pregabalin. The role is related. 2 Sale11@whwingroup.com

3. Wuhan wingroup Pharmaceutical Co.,Ltd., http://www.whwingroup.com/ In vitro experiments have shown that pregabalin may reduce the release of a variety of calcium-dependent neurotransmitters by regulating the function of calcium channels. sal e11@ w hw i ngroup. com sal e11@ w hw i ngroup. com Pregabalin is a structural analogue of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). It does not directly bind to GABAA, GABAB or benzodiazepine receptors, and does not enhance the GABAA response in cultured neurons. Changing the concentration of GABA in the rat brain has a short-term effect on the reuptake and degradation of GABA. However, long-term exposure of cultured neurons to pregabalin increases the concentration of GABA transporter and improves the transport efficiency of GABA. Pregabalin does not block sodium channels, has no effect on opioid receptors, and has no effect on cyclooxygenase activity. Pregabalin has no active effect on serotonin and dopamine receptors, and has no inhibitory effect on the reuptake of serotonin, dopamine and norepinephrine. 4.How can we make pregabalin powder（ capsules（ （drugs） ）？ ？ （raw material） ）to pregabalin ① Pass the pregabalin raw material through a 30-mesh (aperture 600μm) screen on a swing granulator, and then pass the pregabalin raw pwoder through a 30-mesh sieve through a 60-mesh (aperture 250μm) sieve and an 80-mesh (aperture 180μm) sieve in sequence , Take the pregabalin granules that have passed the 60-mesh sieve and the 80-mesh sieve, and set aside; Pass the lactose through an 80-mesh (aperture 180μm) and a 120-mesh (aperture 120μm) sieve on a vibrating sieve, and take the lactose powder that has passed the 80-mesh sieve and the lactose powder that has not passed the 120-mesh sieve for use; 3 Sale11@whwingroup.com

4. Wuhan wingroup Pharmaceutical Co.,Ltd., http://www.whwingroup.com/ Firstly mix the pregabalin granular powder (D50 particle size of 180μm～ 220μm, D90 particle size of 250μm～280μm) obtained in step ① and binder on a multi-directional motion mixer, and then add lubricant and step ② to obtain The lactose granule powder (D50 particle size is 120μm-140μm, D90 particle size is 160μm-180μm), continue to mix uniformly, and finally fill the uniformly mixed material directly on the automatic capsule filling machine to obtain pregabalin capsules. sal e11@ w hw i ngroup. com sal e11@ w hw i ngroup. com 5.What is Pregabalin Used for Pregabalin （Lyrica）is a prescription medicine used in adults, 18 years of age and older to treat: Pain from damaged nerves (neuropathic pain) that happens with diabetes Pain from damaged nerves (neuropathic pain) that follows healing of shingles Fibromyalgia (pain all over your body) Pain from damaged nerves (neuropathic pain) that follows spinal cord injury 4 Sale11@whwingroup.com

5. Wuhan wingroup Pharmaceutical Co.,Ltd., http://www.whwingroup.com/ It is not known if Lyrica is safe and effective in people under 18 years of age for the treatment of fibromyalgia and neuropathic pain with diabetes, shingles, or spinal cord injury. Notice： It is not known if Lyrica is safe and effective in people under 18 years of age for the treatment of fibromyalgia and neuropathic pain with diabetes, shingles, or spinal cord injury. sal e11@ w hw i ngroup. com sal e11@ w hw i ngroup. com Lyrica is a prescription medicine used in people 1 month of age and older to treat: partial-onset seizures when taken together with other seizure medicines. For the treatment of partial-onset seizures when taken together with other seizure medicines, it is not known if Lyrica is safe and effective in children under 1 month of age. 6.Who can and cannot take pregabalin Pregabalin is only for adults. Do not give it to children under the age of 18. Pregabalin is not suitable for some people: To make sure pregabalin is safe for you, tell your doctor if you: have ever had an allergic reaction to pregabalin or another medicine 5 Sale11@whwingroup.com

6. Wuhan wingroup Pharmaceutical Co.,Ltd., http://www.whwingroup.com/ have ever abused or been addicted to a medicine are trying to become pregnant, are already pregnant or are breastfeeding are on a controlled sodium or potassium diet, or your kidneys don't work well – pregabalin liquid contains sodium and potassium, speak to your doctor before taking it sal e11@ w hw i ngroup. com 7.What is Pregabalin Side effects sal e11@ w hw i ngroup. com Like all medicines, pregabalin can cause side effects although not everyone gets them. Common side effects These common side effects may happen in more than 1 in 100 people. They are usually mild and go away by themselves. Keep taking the medicine but tell your doctor if they bother you or don't go away： headaches feeling sleepy, tired or dizzy diarrhoea mood changes feeling sick swollen hands, arms, legs and feet blurred vision for men, difficulties with getting an erection weight gain - because pregabalin can make you feel hungry memory problems If you have diabetes, pregabalin can upset your blood sugar control. Monitor your blood sugar more often for the first few weeks of treatment with 6 Sale11@whwingroup.com

7. Wuhan wingroup Pharmaceutical Co.,Ltd., http://www.whwingroup.com/ pregabalin and adjust your diabetes treatment if you need to. Talk to your doctor or diabetes nurse if you want more advice on what to do. Serious side effects Very few people taking pregabalin have serious problems. Call a doctor straight away if you get: sal e11@ w hw i ngroup. com thoughts of harming or killing yourself - a small number of people taking pregabalin have had suicidal thoughts that can happen after only a week of treatment sal e11@ w hw i ngroup. com difficulties breathing severe dizziness or you pass out hallucinations (seeing or hearing things that aren't real) problems going to the toilet, including blood in your pee, needing to pee more often, or constipation Serious allergic reaction In rare cases, it's possible to have a serious allergic reaction to pregabalin. These are not all the side effects of pregabalin. For a full list see the leaflet inside your medicines packet. 8.How to cope with Pregabalin side effects What to do about: headaches– make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Headaches should usually go away after the first week of taking pregabalin. Talk to your doctor if they last longer than a week or are severe. feeling sleepy, tired or dizzy – as your body gets used to pregabalin, these side effects should wear off. If they do not wear off within a week or 2, your doctor may reduce your dose or increase it more slowly. If that doesn't work you may need to switch to a different medicine. 7 Sale11@whwingroup.com

8. Wuhan wingroup Pharmaceutical Co.,Ltd., http://www.whwingroup.com/ mood changes – if you feel this medicine is causing mood changes , speak to your doctor as you may need a change of medicine. feeling sick – take pregabalin with or after a meal or snack to ease your symptoms. It may also help if you don't eat rich or spicy food. sal e11@ w hw i ngroup. com sal e11@ w hw i ngroup. com swollen hands, arms, legs and feet– if your feet are swollen, try sitting with your feet up on a chair or bed and try not to stand for a long time. Exercise might help if your arms are swollen. If that does not help or it becomes painful, contact your doctor. blurred vision– avoid driving or using tools or machines while this is happening. If it lasts for more than a day or 2 speak to your doctor as they may need to change your treatment. For men, difficulties with getting an erection– speak to your doctor, they may be able to change your medicine or offer other treatments that might help with this problem. weight gain– pregabalin can make you hungrier so it can be quite a challenge to stop yourself putting on weight. Try to eat well without increasing your portion sizes. Do not snack on foods that contain a lot of calories, such as crisps, cakes, biscuits and sweets. If you're hungry between meals, eat fruit and vegetables and low-calorie foods. Regular exercise will also help to keep your weight stable. memory problems– if you're having problems with your memory, speak to your doctor. They may want to try a different medicine Some Key facts about Pregabalin 8 Sale11@whwingroup.com

9. Wuhan wingroup Pharmaceutical Co.,Ltd., http://www.whwingroup.com/ Pregabalin is usually taken 2 or 3 times a day. You can take it with or without food. You don't have to have epilepsy for pregabalin to help with pain or anxiety. It takes at least a few weeks for pregabalin to work. sal e11@ w hw i ngroup. com The side effects of pregabalin are usually mild and go away by themselves. The most common ones are feeling sleepy, dizziness and headaches. sal e11@ w hw i ngroup. com Pregabalin is also called by the brand names Lyrica, Alzain, Lecaent and Rewisca 9.Where to buy Pregabalin Powder（ （raw material） ）CAS 148553-50-8 Pregabalin raw powder CAS 148553-50-8 is the API for the drugs of pregabalin,Pregabalin Powder CAS 148553-50-8 is available online from different manufacturers. Most users of Pregabalin Powder CAS 148553-50-8 buy from different websites, some for retail or wholesale purposes. Verify the legitimacy of every Pregabalin manufacturer using outlined state laws before purchase. We are one of the best Pregabalin Powder CAS 148553-50-8 Suppliers in China，we can supply pregabalin API with high quality and good price. if you interested or want to buy pregabalin，you also can browse our website http://www.whwingroup.com to see more details. 9 Sale11@whwingroup.com

10. Wuhan wingroup Pharmaceutical Co.,Ltd., http://www.whwingroup.com/ 【 【References】 】 1. Summary 2013-03-06 [2013-05-06]. of product characteristics (PDF). European Medicines Agency. 1. Pharmacotherapy Update - Pregabalin (Lyrica®):Part sal e11@ w hw i ngroup. com sal e11@ w hw i ngroup. com 1. Frampton, JE. Pregabalin: a review of its use in adults with generalized anxiety disorder.. CNS Drugs. September 2014, 28 (9): 835–54. PMID 25149863. doi:10.1007/s40263-014-0192-0. 1. Pregabalin. The American Society of Health-System Pharmacists. [2015-10-23]. 10 Sale11@whwingroup.com