Studies on Amphotericin B. Current Formulations and problems and where we fit in!. Scott C. Hartsel Chemistry Department University of Wisconsin-Eau Claire. Overview. An ominous threat What is Amphotericin B? The problem with Amphotericin B What are liposomes and what good are they?
Current Formulations and problems and where we fit in!
Scott C. Hartsel
University of Wisconsin-Eau Claire
Drug therapy:: ketoconazole, fluconazole, Amphotericin B
Binds weakly to AmB
Binds strongly to AmB
Double sided pore
Single sided pore
pores in fungal membranes, causing death or inhibition
Back to Amphotericin...
Hence, reducing effective chemical potential of AmB by “tying up” or by macrophage consumption is key.
Cholesterol channels ≠ Ergosterol channels
TNF-a= fever, anorexia, hypermetabolism and wasting
SCIENCE, Volume 298, Number 5594, Issue of 25 Oct 2002, p. 763.