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EFFECT OF ATYPICAL POPULATIONS IN META-ANALYSIS

EFFECT OF ATYPICAL POPULATIONS IN META-ANALYSIS. Juliana Torres Sánchez PhD. Juan Carlos Correa Morales. AGENDA. Contextualization Problem Design and methods Data/results Next steps…. Contextualization. Sum.

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EFFECT OF ATYPICAL POPULATIONS IN META-ANALYSIS

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  1. EFFECT OF ATYPICAL POPULATIONS IN META-ANALYSIS Juliana Torres Sánchez PhD. Juan Carlos Correa Morales

  2. AGENDA • Contextualization • Problem • Design and methods • Data/results • Next steps….

  3. Contextualization Sum • The meta-analysis is a statistical technique that allows the sum of different studies, to obtain conclusions allowing the unification of results, helping for the understanding of the response variable being analyzed. StatisticalTechnique Understanding Response variable Unification

  4. Problem • Effect Atypical Study Results • Recommendations • Mean, proportions

  5. Studies Meta- Analysis Design and methods µp + k σp Meta-analysis size = N = Sample Size = n 10 Studies + Outlierstudy N = 11 1.000 simulations Proportion (%) = # No Heterogeneity 1.000 Simulations

  6. Design and Methods Atypicalpopulation

  7. Design and Methods

  8. Design and methods

  9. Design and methods

  10. Design and methods

  11. Design and methods

  12. Design and methods

  13. Design and methods

  14. Design and methods

  15. Design and methods

  16. Data/results

  17. In or Out

  18. In when Not Increase the doses Decrease the doses

  19. In when Yes

  20. Out when Not

  21. Out when Yes Decrease the doses True True Increase the doses

  22. ¿Is that or those atypical studies really part of your population

  23. A good approach is to use the linear regression outlier detection proposals

  24. Next steps…. • Othermodels randomeffectsmodel mixedeffectsmodel

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