Case Study Pathogenic Bacteriology 2009. Case # 42 Mamadou Diallo Anne Roberts. Case Summary. 19 year old male student with normal health went to bed with a fever/headache Fever of 40˚c Neck was supple Purpuric rash on legs, trunk and wrists
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Case # 42
of adults. These carriers demonstrate
no symptoms of meningitis and are
primary source of spread through
aerosols, exchange of saliva, etc .
Neck pain, purpuric rash
Gram stain of the blood culture
Gram stain from skin lesions
Growth on chocolate agar with 5 - 10% CO2
Oxidase – Negative
Catalase - Positive
Nitrate Reduction – Positive
Growth on MTM
Carbohydrate utilization tests - Glucose and Maltose positive
Prophylactic strategies in large populations:
Prophylactic Strategies to exposed individuals:
Two mutant strains: double knock out and a single of the gene expressing the LOS from ( N. meningitidis serogroupB)
Mahon, Connie, Donald Lehman, George Manuselis. Textbook of Diagnostic Microbiology. 3rd Edition. Saunders-Elsevier, St. Louis, Missouri, 2007.
Zarantonelli, Maria, et al. 2006. Differential Role of LOS of N. meningitidis in Virulence & Inflammatory Response During Respiratory Infection in Mice, Infection and Immunity, OCT: 5506-5512.