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Agenda. Overview of clinical “pull” What is the overall aim? What are the research challenges?. Ultra-Precise Radiotherapy - Cyberknife. Precise Radiotherapy Target radioresistant regions? hypoxic (oxygen-starved) sections of a tumour. But Hypoxic regions are not static

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Presentation Transcript
agenda
Agenda
  • Overview of clinical “pull”
  • What is the overall aim?
  • What are the research challenges?
ultra precise radiotherapy cyberknife
Ultra-Precise Radiotherapy - Cyberknife
  • Precise Radiotherapy
  • Target radioresistant regions?
    • hypoxic (oxygen-starved) sections of a tumour.
  • But
    • Hypoxic regions are not static
    • Imaging (eg CT) is a snapshot
  • Also – can we measure cancercell kill?
  • Implanted sensing …
  • Ian, David
real time tumour monitoring
Real Time Tumour Monitoring

Miniaturised sensors

pH, T, O2, conductivity

Implant sensorssurgically into the tumour

microenvironment

before radiotherapy

Sensor chip around

7mmx500μmx500μm …

the size of a grass seed

sensors and therapy
Sensors and Therapy

A group of cancer cells

sensors and therapy1
Sensors and Therapy

RT-Resistant (1) and RT-sensitive cells (2) and other stuff (3, 4)

sensors and therapy3
Sensors and Therapy

Chips detect and signal RT-resistant zones

sensors and therapy4
Sensors and Therapy

Deliver extra RT dose to resistant zones

more direct measures than o2
More “direct” measures than O2?
  • Caspases
    • “the executioners of cell death”
  • Hypoxia Inducible Factor (HIF)
  • Ian/David (why?)
  • Mark/Andy (how?)
sensors and therapy5

Target radiotherapy sensor chip powered down

Find radio-resistant regions

Measure cancer cell kill

Sensors and Therapy

Implant sensors in vivo

implications personalised therapy
Implications – Personalised Therapy
  • Improved targetting of radiotherapy
    • Different scheduling strategy
  • Improved cure rates for many solid cancers
  • Potential for implanted, local chemotherapy
  • Major change to NHS practice
  • Regulation? Acceptability? Value Systems?
  • Joyce
social sciences joyce tait
Social Sciences

JoyceTait

Implantable Microsystems for Personalised Anti-Cancer Therapy (IMPACT)

Engineering

Alan Murray, Anthony Walton, Steve McLaughlin

Chemistry

Mark Bradley

Cancer Medicine

Ian Kunkler

Veterinary Medicine

David Argyle