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Mesporin: Mepha Health Care.. for Post-operative Infection. Postoperative Infections, Simple Facts. The most common postoperative infections include: - Local infection: Surgical site (wound) infection, Intra-abdominal infection & abcess , - Remote infections:

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mesporin mepha health care for post operative infection

Mesporin:Mepha Health Care.. for Post-operative Infection

The innovative Swiss pharmaceutical company

postoperative infections simple facts
Postoperative Infections,Simple Facts

The innovative Swiss pharmaceutical company

slide3

The most common postoperative infections include:

- Local infection:

  • Surgical site (wound) infection,
  • Intra-abdominal infection & abcess,

- Remote infections:

  • Respiratory tract infection,
  • Urinary tract infection,
  • The rates of surgical site and respiratory infections are less with laparoscopic surgery; however, in some studies laparoscopic surgery seems to cause a higher incidence of postoperative intra-abdominal abscess¹.

1: Boni et al; Infective Complications in Laparoscopic Surgery. Surgical Infections. Summer 2006, 7(supplement 2): s-109-s-111.

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preventing surgical infections
Preventing Surgical Infections

Antibiotic prophylaxis

  • Drugs: which, when, how many doses?

Non antibiotic measures- evidence based:

  • Hair removal
  • Normothermia
  • Oxygen supplementation
  • Normoglycemia
antibiotic rationale what should we choose
Antibiotic rationale –what should we choose?
  • Deal with the common pathogens encountered at the surgical site
  • One that is bactericidal
  • One that achieves adequate local soft tissue concentrations
  • One that is non toxic with minimal side effects
  • One that has a long serum half life
  • Ideally one that has a low risk of inducing resistance

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for such serious need in surgery
For such serious need in surgery…

has developed an innovative antibiotic..

The innovative Swiss pharmaceutical company

ceftriaxone prophylaxis general gynecological surgery
Ceftriaxone ProphylaxisGeneral & Gynecological Surgery

The innovative Swiss pharmaceutical company

slide8

Postsurgical infections varies in site, severity, & causative micro-organisms.

  • Therefore, 2 or 3 antibiotic combinations are usually used, as well as broad & ultra-broad spectrum antibiotic monotherapy.
  • To evaluate the role of surgical prophylaxis with ceftriaxone versus other antibiotics, a meta-analysis of 48 clinical studies were performed involving 17, 565 patients*.

* Esposito et al; Ceftriaxone versus Other Antibiotics for Surgical Prophylaxis: A Meta-Analysis. Clinical Drug Investigation: 2004 - Volume 24 - Issue 1 - pp 29-39.

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results
Results:

Incidence of postoperative infections

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conclusions
Conclusions:
  • The meta-analysis showed that ceftriaxone is statistically superior to other antibiotics in preventing both local and remote postoperative infections.

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slide11

The antibiotic of choice

Once daily therapy

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slide12

MesporinTM

is a sterile, lyophilized, semi-synthetic, long-acting, parenteral (intravenous

and intramuscular), broad-spectrum bactericidal antibiotic.

The chemical formula of ceftriaxone sodium

References:

Zimmermanns M. Index Infektionen Erreger Antibiotika. 1989

slide13

Properties and effects

  • The bactericidal activity of ceftriaxone results from inhibition of the
  • bacteria’s wall synthesis.
  • Ceftriaxone exerts activity against both Gram-negative and
  • Gram-positive aerobic and wide range of anaerobic microorganisms.
  • Ceftriaxone is highly stable to most β-lactamases, both penicillinases and
  • cephalosporinases, of Gram-negative and Gram-positive bacteria.

References:

Zimmermanns M. Index Infektionen Erreger Antibiotika. 1989

slide14

Pharmacokinetics of ceftriaxone

  • Half-life of ceftriaxone is generally about 6 to 10 hours in
  • healthy adult subjects.
  • The exceptional pharmacokinetic characteristics of ceftriaxone
  • (MesporinTM) supports a once-daily dosing in every clinical
  • conditions and patient age.
  • A high plasma and tissue concentration after both i.v. and i.m.
  • administration simplifies the treatment and ensures an effective
  • bactericidal tissue concentration during 24 hours.

References:

Physician’s Desk Reference. 54th edition, 2000

Borgden R., Ward A. Drugs. 1988;35;604–645

Patel I. et al. Antimicrob Agents Chemother. 1981;20;634–641

Stoeckel et al. Current Chemotherapy and immunotherapy. 1982;Vol.1;454–455

the antibiotic of choice
The antibiotic of choice
  • Compensatory excretion through the kidney and liver

prevents accumulation in case of impairment of one or

the other.

  • Dual and balanced excretion Via Renal and Biliary pathways

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why mesporin
Why Mesporin?

ONCE DAILY

TOP SWISS QUALITY

Lyophilized ceftriaxone

Deep tissue penetration

Dual excretion pathways

The innovative Swiss pharmaceutical company

thank you

Thank You

The innovative Swiss pharmaceutical company