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IgE FcɛRI Signalling Pathway in Allergy and Cancer: Understanding Molecular Reactions

Explore the mechanisms of IgE FcɛRI signalling pathway and its implications in allergy and cancer. Learn about the binding of IgE, receptor aggregation, Lyn-Syk pathways, degranulation, and immune responses against tumor cells. Discover IgE-based treatment options and the inverse association between IgE and malignancies, highlighting the potential for novel therapeutic interventions. Simplify chemical reactions with Bngl for better comprehension and precise manipulation of molecule concentrations and reaction timeframes.

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IgE FcɛRI Signalling Pathway in Allergy and Cancer: Understanding Molecular Reactions

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Presentation Transcript

  1. FcɛRI Signalling Pathway

  2. The Ligand : IgE

  3. Mast and Basophil Cells

  4. Fc receptors bind tail region of IgE antibodies. • Histamine, proteases,

  5. The Receptor

  6. Tyrosine Kinases Lyn Syk

  7. The Pathway • Binding of IgE • Aggregation of receptors

  8. Lyn binds beta unit of one receptor and transphosphorylates the beta ITAM, gamma ITAM, and Syk associated with adjacent receptor. Syk can also phosphorylate syk associated with adjacent receptor Syk activation Cascade of reactions Degranulation

  9. Allergy sufferers are at a lower risk of developing cancer

  10. Inverse association between IgE and malignancies • IgE-mediated immune responses against tumor cells  • IgE-based treatment options

  11. Histogram not generating all first passage times

  12. But it wasn't so bad • Bngl easy to understand • Easy to define chemical reactions • Can manipulate molecule concentrations • Can set time period of reaction

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