Metals in medicine research university of wollongong
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Institute for Biomolecular Science (IBS) 14 Academic Staff Dept. of Chemistry Dept. of Biology 9 Postdocs 30 PhD Students B. Med Chem B. Biotech . Project areas include: Drug design and development Biomolecular structure determination Cellular and molecular biology

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Metals in medicine research university of wollongong

Institute for Biomolecular Science (IBS)

14 Academic Staff

Dept. of Chemistry

Dept. of Biology

9 Postdocs

30 PhD Students

B. Med Chem

B. Biotech

Project areas include:

Drug design and development

Biomolecular structure determination

Cellular and molecular biology

Food and natural product chemistry

Mechanism of cataract formation

Metals in Medicine Research University of Wollongong



How does chrysotherapy work
How does Chrysotherapy Work?

  • Many possible mechanisms of action:

    • Anti-inflammatory

    • Inhibition of lysosomal enzymes

    • Immunomodulatory activity

    • Effects on metabolism of reactive oxygen

  • All gold drugs rapidly bind to proteins containing thiol side chains, but not DNA.

  • [Au(CN)2]- is a common metabolite of all Au drugs

  • Au(I) oxidised to Au(III) in vivo


Esi ms of human serum albumin hsa
ESI-MS of Human Serum Albumin (HSA)

J. Croft, CHEM340, 2004


Reaction between au pet 3 cl and metallothionein
Reaction between [Au(PEt3)Cl] and Metallothionein

S. Ambehara, B.Sc(Hons), 20002



Non covalent interactions between ruthenium complexes and dna
Non-covalent Interactions Between Ruthenium Complexes and DNA

J. Aldrich-Wright and co-workers


Esi ms of d2
ESI-MS of D2 DNA

[D2-6H]6-

[D2-5H]5-

T. Urathamakul, B.Sc(Hons), 2002


Esi ms of ru phen 2 dpqc 2 mol wt 748
ESI-MS of [Ru(phen) DNA2(dpqC)]2+(mol. wt = 748)

T. Urathamakul, B.Sc(Hons), 2002


Reactions between ru phen 3 2 and d2
Reactions between [Ru(phen) DNA3]2+ and D2

T. Urathamakul, B.Sc(Hons), 2002

Ru:D2 = 5:1

Ru:D2 = 10:1

Ru:D2 = 20:1

Ru:D2 = 30:1

Ru:D2 = 50:1


Reactions between ru phen 2 l 2 and d2
Reactions between [Ru(phen) DNA2L]2+ and D2

L = phen

L = pda

L = dpq

L = dpqMe2

L = dpqC

T. Urathamakul

B.Sc(Hons), 2002

L = dppz


Future work
Future Work DNA

  • Binding of mono- and poly-nuclear ruthenium complexes to longer DNA and DNA containing other base sequences

  • Binding of gold, vanadium, bismuth, ruthenium and other metal-containing drugs to proteins including HSA, MT and Transferrin