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Investigating K-RasGV12 and Proteolytic Enzymes in Cancer Dynamics

This study delves into the role of K-RasGV12 in cancer progression, focusing on its interaction with various proteolytic enzymes, including ADAM10, ADAM15, ADAM17, and CTSL. We also explore the implications of these interactions on tumor microenvironments, emphasizing GFP tagging for in vivo visualization. The findings aim to elucidate how these enzymes, alongside caspases and MT1-MMP, contribute to tumor invasion and metastasis, offering potential therapeutic targets for cancer treatment.

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Investigating K-RasGV12 and Proteolytic Enzymes in Cancer Dynamics

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  1. Additional File 1 A K-RasGV12/ E1 K-RasGV12/ E1-R3 ADAM10 ADAM15 ADAM17 CTSL CTSV GFP PLAU CASP 7 CASP 8 CASP 9 MT1-MMP B

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