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Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat fa

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Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat fa - PowerPoint PPT Presentation


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Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve . Eileen M. Foecking, PhD; Keith N. Fargo, PhD; Lisa M. Coughlin, MD; James T. Kim, MD; Sam J. Marzo, MD; Kathryn J. Jones, PhD . Aim

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slide1

Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve

Eileen M. Foecking, PhD; Keith N. Fargo, PhD; Lisa M. Coughlin, MD; James T. Kim, MD; Sam J. Marzo, MD; Kathryn J. Jones, PhD

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Aim

    • Test whether electrical stimulation (ES) adminis-tered immediately after crush injury further decreases time for complete recovery from facial paralysis.
  • Relevance
    • Peripheral nerve injuries lead to various conditions, including paresis or paralysis.
    • Daily ES to facial nerve proximal to injury affects early events in nerve regeneration process in rats by initiating axon sprout formation.
methods
Methods
  • Rats received unilateral facial nerve crush injury.
    • Electrode positioned on nerve proximal to injury.
  • Rats received 30 min of ES daily for:
    • 1 d (day of injury), 2 d, 4 d, 7 d, or daily until complete functional recovery.
    • Untreated animals received no ES.
  • Rats were observed daily for return of facial function.
results
Results
  • One session of ES was as effective as daily stimulation at enhancing recovery of most functional parameters.
conclusions
Conclusions
  • Use of one 30 min session of ES should be studied as possible treatment strategy for human patients with paralysis as result of acute nerve injuries.