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Rob Ridley Director, TDR

Sustaining Priority Research for Neglected Tropical Diseases. Rob Ridley Director, TDR. TDR 'twin' Mission. To undertake research, development and evaluation of new and improved tools and interventions to fight major tropical diseases

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Rob Ridley Director, TDR

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  1. Sustaining Priority Research for Neglected Tropical Diseases Rob Ridley Director, TDR

  2. TDR 'twin' Mission • To undertake research, development and evaluation of new and improved tools and interventions to fight major tropical diseases • To strengthen research capabilities in countries where these diseases are endemic • enhanced stakeholdership / ownership of research

  3. A vicious cycle DISEASE POVERTY

  4. Many 'Neglected Diseases' Mortality Estimates for 2002 (World Health Report 2004) • Infectious and Parasitic diseases 10 904 (000) • HIV/AIDS 2 777 ¨ • Diarrhoeal diseases 1 798 ¨ • Tuberculosis 1 566 ¨ • Malaria 1 272 ¨ • Childhood diseases 1 124 ¨ • STI (excluding HIV) 180 ¨ • Meningitis 173 ¨ • (Other) Tropical Diseases 129 ¨ • Hepatitis B 103 ¨ • Hepatitis C 54 ¨ • Dengue 19 ¨ • Japanese encephalitis 14 ¨ • Intestinal nematode 12 ¨ • Leprosy 6 ¨

  5. 'Neglected' Diseases affect 'Neglected' Populations

  6. Priority Setting

  7. Tropical Disease Burden Poverty Poverty Control/ Elimination Of Tropical Diseases reduction Strategy ??

  8. Innovation to Impact Grand Challenges NIH, Trust, Research councils etc.

  9. Need to sustain and increase basic science funding

  10. Product Development

  11. Examples of public private partnerships that have delivered new tools

  12. Innovation to Impact – product development EDCTP MMV Microbicides DNDi GATB IAVI FIND MVI

  13. 8 new drugs anticipated by 2010 Proposed fund of $200M per year to complement PPP's Product Development Activities Need Sustaining

  14. Much variation by disease (e.g. Gates)

  15. Evaluation and Implementation Research

  16. Examples of TDR – mediated evaluation and implementation research • Onchocerciasis • Ivermectin and Community Directed Treatment • Malaria • Home management of malaria strategies • Visceral Leishmaniasis • Tools in place for 'elimination' programmes A critical area for future funding given increase of tools in pipeline

  17. Example in progress Visceral Leishmaniasis New tools stimulate India / Nepal / Bangladesh to sign MoU for elimination of VL by 2015 • Local ownership of research critical • Recognition of significance of social, economic and behavioural research • Research must be embedded in and owned by countries and integrated into health systems • Inter-country coordination facilitated by WHO / SEARO / TDR • Requires a co-ordinated approach by partners for maximal impact

  18. Innovation to Impact

  19. Innovation to Impact

  20. Look beyond single issuesManaging Interfaces

  21. Challenges No. 1 • Maintained funding for basic science, continued innovation and PPP product development • Better balance for more neglected diseases • Better management of translation research • Enhanced Evaluation and Implementation Research for all diseases • Enhanced coordination and interaction between initiatives, funding agencies, governments and regional bodies • Role for international agencies

  22. Look beyond single issuesCross-cutting issues

  23. Challenges No. 2 • Need capacity building coupled to capacity utilisation • Need to enhance country participation, 'stakeholdership' and ownership of research • Need to 'embed' the output of research activities within the institutions of developing countries • Need to enhance capabilities of developing countries to engage in 'innovation' as well as implementation

  24. Use-inspired Research

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