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HPLC profiling of Trp-related metabolites in human

Summary: Screening for metabolic abnormalities of Trp has been introduced, using SPE pre-treatment, TLC and/or two RP-HPLC procedures. The excretory pattern in urine (occasionally also plasma and CSF levels) has been followed in a group of 390 children showing various symptoms of a metabolic defect and in 195 patients with skin diseases, namely those associated with photosensitivity, such as porphyria, vitiligo, alopecia, psoriasis, erythematodes, and others. Excretory abnormalities of either in31632

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HPLC profiling of Trp-related metabolites in human

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    7. ALGORITHM of the proposed investigation involves 2-3 steps; no Trp load has been practised so far; SPE isolation, followed directly by HPLC has been mostly used in this study for the skin-patients group.

    8. TLC (urine; UV 254. 366 nm / Ehrlich detection)15

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