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Neuro Unit 5.6: Long-term effects of drug abuse and addiction. Do Now:. Compare the structure of the two neurons below. How and why might they be different?. Repeated Exposure to Methamphetamine. Normal. What causes these changes?. Neurons are made of many different proteins.

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do now
Do Now:
  • Compare the structure of the two neurons below.
  • How and why might they be different?

Repeated Exposure to Methamphetamine

Normal

what causes these changes
What causes these changes?
  • Neurons are made of many different proteins.
  • Changes in these proteins change neuron structure.

nucleus

synapse

how are proteins changed
How are proteins changed?
  • What within the cell contains the code for proteins?

DNA

where are proteins synthesized
Where are proteins synthesized?

Nucleus

DNA

Cytoplasm

Protein

How does the DNA code in the nucleus get into the cytoplasm for proteins to be made?

rna transports the code to the cytoplasm
RNA transports the code to the cytoplasm

Nucleus

DNA

RNA

Cytoplasm

Protein

the central dogma
The Central Dogma
  • Describes how proteins are synthesized.

DNA

RNA

Protein

Replication

Translation

Transcription

neuronal stimulation causes protein s ynthesis
Neuronal stimulation causes protein synthesis

Nucleus

DNA

RNA

Cytoplasm

Protein

  • Drug abuse causes overstimulation of neurons.
  • What effect would overstimulation have on protein synthesis?
neuronal stimulation causes protein s ynthesis1
Neuronal stimulation causes protein synthesis

Nucleus

DNA

RNA

  • Overstimulation increases the number of proteins.
  • Proteins assemble synapses.
  • What effect would increased protein synthesis have on the number of synapses?

Cytoplasm

Proteins

neuronal stimulation causes protein s ynthesis2
Neuronal stimulation causes protein synthesis

Nucleus

DNA

RNA

Cytoplasm

  • Overstimulation increases the number of synapses.

Proteins

  • What effect would increasing the number of synapses have on network function?
  • The network would function abnormally.
the b rain s reward circuit
The brain’s reward circuit

Prefrontal Cortex

VTA

Normal Synapses

NAc

the b rain s reward circuit1
The brain’s reward circuit

Cocaineor drug of abuse

Prefrontal Cortex

VTA

Abnormal Synapses

NAc

drug use changes neuronal structure
Drug use changes neuronal structure

Normal Synapses

Abnormal Synapses

  • Once abnormal synapses have formed, would you need more or less of a drug to activate all these synapses?
  • You would need more drug to activate all the synapses

Repeated Drug Use

tolerance
Tolerance
  • Needing more of a drug to have the same biological effect.

Or

  • Decreased response to a drug with repeated exposure.
drug use changes neuronal structure1
Drug use changes neuronal structure

Normal Synapses

Abnormal Synapses

  • Once abnormal synapses have formed, what would happen if you stopped using the drug?
  • The network would function abnormally – WITHDRAWAL SYMPTOMS.

Repeated Drug Use

wrap up
Wrap Up:
  • The reward pathway is composed of the VTA, NAc and prefrontal cortex.
  • The DNA expression of which of these structures is altered by drugs of abuse?
    • The DNA of all the these structures is altered by repeated drug use.
  • How does this alter their physical structure?
    • Drug use causes an increase in the number of synapses.
homework
Homework
  • Choose a drug of abuse and research treatment options for someone addicted to that drug.
the central dogma1
The Central Dogma
  • Describes how proteins are synthesized.

DNA

RNA

Protein

Replication

Translation

Transcription

where are proteins synthesized1
Where are proteins synthesized?

Nucleus

Cytoplasm

DNA

Protein

  • But, how does the DNA code in the nucleus get to the cytoplasm for proteins to be made?
rna transports the code to the cytoplasm1
RNA transports the code to the cytoplasm

Nucleus

Cytoplasm

DNA

RNA

Protein