Pathology of Amyloidosis
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of wellbeing only includes themselves,
their own family, community, race,
religion or nation.”
Selfishness is the cause of evil…!
The foundation of Clinical Medicine.
Shashidhar Venkatesh Murthy
A/Prof & Head of Pathology
College of Medicine & Dentistry
Group of disorders with extracellular
deposition of fibrillary non digestible
abnormal (misfolded) proteins waxy material
(> 20 different proteins).
“Amyloid” (starch like - Virchow) due to
charged sugar molecules in the protein.
Routine Microscopy shows as uniform pink
Congo red stain – specifically stains
amyloid – red which apear apple green
under polarized microscopy.
Systemic / Local & Hereditary types.
cardiomyopathy & organ failure.
Glomerulus - Congo Red Stain
Amyloidosis: Types & their Pathogenesis:
Senile / Hereditary
Amyloidosis: Clinical Disorders
Systemic Amyloidosis: (multiorgan)
Primary: Plasma cell / Immunocyte disorders: Multiple myeloma. - AL
Secondary: Reactive, Chronic Inflam. TB, Auto.Imm dis. – AA
Hemodialysis Associated: Chronic Renal Failure – β2 microglob.
Systemic Senile Amyloidosis: Ageing Transthyretin, cardiomyopathy ATTR
Hereditary Amyloidosis: Many subtypes, familial: ATTR
ATTR: Amyloid of TTR transporter of Thyroxin & Retinol (VitaminA)
Localized Amyloidosis: (Specific tissue / organ)
Senile cerebral: Alzheimer disease Aβ
Endocrine: Diabetes DM2 – AIAPP Proinsulin.
Cardiac Amyloidosis: atrial natriuretic factor. AANF
Medullary carcinoma thyroid – ACal – Calcitonin.
people whose idea of
wellbeing only -- Sadhguru
Think before thinking negative..…!
Senile Systemic Amyloidosis – Heart, Restrictive CMP
Previously known as Senile Cardiac Amyloidosis.
Restrictive Cardiomyopathy & Arrhythmias.
American Black population 4%, Transthyretin (ATTR)
Familial amyloid polyneuropathy (FAP): Sweden, Japan, common.
Gross: Organ enlargement, pale, rubbery firm (waxy deposits)
Microscopy: extracellular Pink deposits. Congo Red stain +ve.
Effects: Pressure atrophy of surrounding cells, Narrowing of BV.
Ischemia, infarctions, dysfunction / hypofunction.
idea of wellbeing only -- Sadhguru
Extracellular deposition of waxy, misfolded, non digestible proteins
with β pleated fibrillary structure.
Leading to cellular damage & organ failure.
Primary, Secondary, Systemic, Localized & Hereditary types.
Secondary Amyloidosis, Commonest, chronic inflammation. SAA.
Clinical: Hepatosplenomegaly, brain, kidney & Heart failure
Gross: Firm, pale, waxy enlargement of organs.
Microscopy: Extracellular, pink protein.
Congo red stain positive, apple green under polarized microscopy.
Late complication in chronic infections(TB), Inflammations,
Autoimmune disorders, Ageing and B cell neoplasms like multiple
myeloma. Rarely hereditary disorders.
but above it is Character”
Knowledge without character is dangerous!