polymyositis and dermatomyositis bohan and peter n engl j med 1975 292 344 n.
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Polymyositis and Dermatomyositis Bohan and Peter, N Engl J Med 1975, 292:344. Symmetrical weakness of the limb girdle muscles and anterior neck flexors, progressing over weeks to months, with or without dysphagia or respiratory muscle involvement

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Polymyositis and Dermatomyositis Bohan and Peter, N Engl J Med 1975, 292:344


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    1. Polymyositis and DermatomyositisBohan and Peter, N Engl J Med 1975, 292:344 • Symmetrical weakness of the limb girdle muscles and anterior neck flexors, progressing over weeks to months, with or without dysphagia or respiratory muscle involvement • Muscle biopsy evidence of necrosis of myofibers, phagocytosis, regeneration with basophils, large vesicular sarcolemmal nuclei, and prominent nucleoli, atrophy in a perifascicular distribution, variation in fiber size and an inflammatory exudate, often perivascular • Elevation in serum of skeletal-muscle enzymes, particularly the CK and often aldolase, aspartate aminotransferase (AST or SGOT), alanine aminotransferase (ALT or SGPT) and lactate dehydrogenase (LDH) • Electromyographic triad of short, small, polyphasic motor units, fibrillations, positive sharp waves and insertional irritability, and bizarre, high frequency repetitive discharges • Any one of the characteristic dermatologic features of the rash of DM