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Chapter 16 (Part 4). Synthesis of Eicosanoids, Glycerolipids and Isoprenoids. Eicosanoids. Eicosanoid Synthesis. cyclooxygenase. Glycerolipid Biosynthesis. Phosphomevalonate kinase. pyrohosphomevalonate decarboxylase. Mevalonate kinase. Formation of the isopentenyl pyrophosphate (IPP).

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chapter 16 part 4

Chapter 16 (Part 4)

Synthesis of Eicosanoids, Glycerolipids and Isoprenoids

eicosanoid synthesis
Eicosanoid Synthesis

cyclooxygenase

slide10

Phosphomevalonate

kinase

pyrohosphomevalonate

decarboxylase

Mevalonate

kinase

Formation of the isopentenyl pyrophosphate (IPP)

condensation of ipp into polyprenyl compounds
Condensation of IPP into Polyprenyl Compounds

IPP

isomerase

Dimethylallyl

pryophosphate

slide14

IPP Isomerase

prenyltransferase

prenyltransferase

Squalene synthase

Cholesterol Synthesis from IPP

slide15

Squalene

monooxygenase

2,3-oxidosqualene

lanosterol cyclase

20 steps

cholesterol