Chapter 16- Tolerance and autoimmunity. Where we’re going- Brief look at just a few diseases- A longer look at theoretical causes. Experimental models. Mice that get diseases like diabetes and lupus Experimental systems. Complete Freund’s adjuvant- big stimulator of the immune system!.
EAE, heart attack Ab’s, anti-sperm Ab’s post-vasectomy
IDDM Pancreatic cells- hi levels of MHC I &II! 20-9
A viral peptide is presented by MHCII- it looks like self- stimulates self-rxtive Th cell- Self-peptides are not normally on MCHII!
LPS, EBV in mono- AIDS patients have viruses & non-specific Ab’s.
Vaccinate with dead specific Tcells
Competitively inhibit binding of bad peptides with similar peptides.