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CLASSIFICATION. - PowerPoint PPT Presentation


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CLASSIFICATION. Classified into 4 species or subgroups based on biochemical & serological characteristics. 1.Sh.dysenteriae. 2.Sh.flexneri 3.Sh.boydii. 4. Sh.sonnei . Colicin typing. Sh.dysenteriae . mannitol nonfermenting bacilli. 10 serotypes Indole -negative Catalase -negative.

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slide2

Classified into 4 species or subgroups based on biochemical & serological characteristics.

  • 1.Sh.dysenteriae.
  • 2.Sh.flexneri
  • 3.Sh.boydii.
  • 4. Sh.sonnei.
  • Colicin typing.
slide3

Sh.dysenteriae.

  • mannitolnonfermenting bacilli.
  • 10 serotypes
  • Indole-negative
  • Catalase-negative
slide4

10 serotypes.

  • Type 1-shiga toxin.
  • Type 2-indole negative(Sh.schmitzi)
  • Type 3-7(large sachs group)
slide5

3 types of toxic activities of shiga toxin.

  • 1.neurotoxicity.
  • 2.enterotoxicity
  • 3.cytotoxicity
slide6

NEUROTOXICITY

  • Demonstrable by paralysis & death on injection into mice & rabbits.
  • Neurotoxin.
  • Primary site of action appears to be not nervous tissue but the blood vessels of the CNS
slide7

ENTEROTOXICITY

  • Induction of fluid accumulation in ligated rabbit ileal loop.
  • Sh.ET 1&2
slide8

CYTOTOXICITY

  • Cytopathic changes in cultured Vero cells.
  • Toxin consists of binding(B) & active(A) subunits.
  • Subunit A is divided into A1 &A2 fragments.
slide9

Sh.flexneri

  • Mannitol fermenting.
  • Antigenically most complex.
  • Based on type specific & group specific antigens-6 serotypes.
  • Two antigenic variants-X&Y.
slide10

Sh.boydii

  • Consists of Dysentery bacilli similar to Sh.flexneri biochemically but not antigenically.
  • 15 serotypes
slide11

Sh.sonnei

  • Late fermenters of lactose & sucrose
  • Indole negative.
  • Antigenically homogenous-but may occur in 2 forms phase1& phase2
slide12

Mildest form of bacillary dysentery

  • Most common shigellosis in advanced countries.