chapter 32 Viral Pathogenesis. Samar Abu Ouda 20060282. Pathogenesis & Immunopathogenesis. **The signs and symptoms of most viral diseases undoubtedly are the result of cell killing by virus-induced inhibition macromolecular synthesis e.g. poliovirus, Ebola virus.
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Samar Abu Ouda20060282
**The signs and symptoms of most viral diseases undoubtedly are the result of cell killing by virus-induced inhibition macromolecular synthesis
e.g. poliovirus, Ebola virus
There are other diseases in which cell killing by immunological attack plays an important role in pathogen
(1)lymphocyte chorio meningitis (LCM) in mice
) Immune-mediated pathogenesis3)
For example, there are strains of poliovirus that have mutated sufficiently such that they have lost the ability to cause polio in immunocompetent individuals;
. In addition, some viruses (e.g., HIV, cytomegalovirus- virus) can reduce the expression of class I MHC proteins, thereby reducing the ability of cytotoxic T cells to kill the virus-infected cells, and others (e.g., herpes simplex virus) inhibit complement.
A. CHRONIC-CARRIER INFECTIONS
B. LATENT INFECTIONS
C. SLOW VIRUS INFECTIONS
the virus has been shown to have a normal, not prolonged, growth cycle.