1 / 6

Pleiotropy

Pleiotropy. Definition. The ability of a gene to affect more than one characteristic. A. Several characteristics are affected by the single gene. B. C. Sickle cell disease. The gene Hb codes for production of haemoglobin. Hb s is a mutation. Mutant haemoglobin results in:

vidor
Download Presentation

Pleiotropy

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Pleiotropy

  2. Definition • The ability of a gene to affect more than one characteristic. A Several characteristics are affected by the single gene B C

  3. Sickle cell disease • The gene Hb codes for production of haemoglobin. • Hbs is a mutation. • Mutant haemoglobin results in: • Brain damage • Heart and blood vessel damage • Spleen enlargement then atrophy • Kidney damage leading to blood in urine

  4. PKU (phenylketonuria) • The PKU gene codes for the enzyme phenylalanine hydroxylase. • This enzyme converts the phenylalanine to tyrosine. Both are amino acids. • Mutations to the gene result in: • Mental retardation • Reduced hair and skin pigmentation • Damage to body parts from toxic levels of phenylalanine • PKU is totally benign if a diet free from phenylalanine is maintained.

  5. Fruit fly and vestigial wing • The vestigial gene plays a critical role in wing development. • vv will develop short wings • The affects are: • Cannot fly • Number of egg strings in a fly's ovaries changes • Position of bristles on a fly's scutellum alters, • Length of a fly's life decreases

  6. Pigmentation and deafness in cats • About 40% of cats with white fur and blue eyes are deaf • The gene affects pigmentation as well as ability to hear • Pigmentation may play a role in maintaining fluid in ear canals

More Related