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Immunology: Complement System Components and Activation

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  1. Complement Hugh B. Fackrell & Maria Sawicki

  2. Complement • Assigned Reading • Content Outline • Performance Ojectives • Key terms • Key Concepts • Short Answer Questions

  3. Assigned Reading • Chapter: 14 pp 335-356 • Janis Kuby’s Immunology 3rd Ed

  4. Complement Components Complement Activation Regulation of Complement Biological Consequences Complement Deficiences Content Outline

  5. Complement system

  6. Phases in the Complement Cascade • Recognition • Activation Amplification • Membrane Attack

  7. Complement Cascade

  8. Complement Activation • Classical pathway • Alternative pathway • Membrane attack complex

  9. Complement Components The Classical Pathway

  10. Membrane Bound Antigens

  11. Soluble Antigen

  12. Complement C1q EM

  13. C1rC1Sa

  14. C1rC1sC

  15. C1rC1Sb

  16. C4 polypeptide

  17. C4 hydrolysed

  18. C4 disulfides

  19. C4

  20. C2a

  21. C2b

  22. C3

  23. C3b

  24. C5

  25. C5a & C5b

  26. C6

  27. C7

  28. C7 becomes hydrophobic

  29. C8

  30. C8 in membrane

  31. C9

  32. C9 pore

  33. C5b-9 EM

  34. Complement induced Lysis

  35. An Alternative Complement Pathway Part of Innate immunity Activated without Antibody

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