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Long QT

Long QT. By Courtney Colen. Alternate names. There is no alternate name for Long QT. Who can get this?. Anyone can get this. If 1 person has been diagnosed in a family. All family members should be tested for LQT. Symptoms. This mutation is found in the heart

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Long QT

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  1. Long QT By Courtney Colen

  2. Alternate names • There is no alternate name • for Long QT.

  3. Who can get this? • Anyone can get this. If 1 person has been diagnosed in a family. All family members should be tested for LQT.

  4. Symptoms • This mutation is found in the heart • You cannot tell if a person has LQT by looking at them • Fainting- This is the most common sign of long QT. In people with long QT syndrome, fainting spells are caused by the heart temporarily beating in an un normal way. These may happen when you're excited, angry or scared, or while exercising. Fainting in people with long QT can occur without warning. • Signs and symptoms before fainting include lightheadedness, irregular heart beat, and blurred vision. It is uncommon though that warnings are given before you faint. • Seizures- when the heart consistently beats un-normally the brain becomes deprived of air.

  5. How common? • Long QT is a lot more common then originally thought. Every 1 person in 5000 to 7000 has long QT. Most unexplained deaths in children and young adults seems they had long QT.

  6. Deadly? • This can be deadly. If found early enough it can be treated. • Children, teenagers and young adults with unexplained fainting, unexplained near drowning or other accidents, unexplained seizures, or a history of cardiac arrest may have long QT.

  7. Tests • An electrocardiogram (ECG) • Ambulatory ECG monitoring • Event ECG recording • A non-exercise (medication) stress test • An electroencephalogram (EEG). • Genetic testing

  8. Treatment • Treatment for long QT syndrome include medications, medical devices, or surgery. • Medications-BetaBlockers -Mexiletine -Potassium -Fish Oil • Medical Devices and Surgery- -Pacemaker -Left cardiac sympathetic denervation surgery

  9. Support Groups • Families with long QT may find it helpful to talk to a cardiologist with expertise in diagnosing and treating long QT, a genetics counselor, a psychiatrist or psychologist, as well as other families with the condition.

  10. Inheritance pattern • Long QT is Dominant not recessive • Prolonged QT is autosomal • It is not sex-linked • Mutations found in 5 ion channel

  11. What Chromosome? • Long QT is on chromosome 11. another form LQT2 is on chromosome 7.

  12. Interesting Facts • There are different forms of long QT. • LQT2 • alpha subunit of the rapid delayed rectifier potassium channel • LQT3 • alpha subunit of the sodium channel • LQT4 • anchor protein Ankyrin B • LQT5 • beta subunit MinK which co assembles with KvLQT1 • LQT6 • beta subunit MiRP1 which co assembles with HERG

  13. Facts (con’t) • LQT7 • potassium channel, leads to Andersen-Tawil syndrome. • LQT8 • alpha subunit of the calcium channel Cav1.2 encoded by the gene, Leads to Timothy's syndrome. • No information about the following • LQT9 • LQT10 • LQT11 • LQT12 • LQT13

  14. Pictures

  15. Works Cited • http://www.hrsonline.org/PatientInfo/HeartRhythmDisorders/IDisorders/index.cfm • www.mayoclinic.com/health/long-qt-syndrome/DS00434 • http://jmg.bmj.com/content/38/10/705.extract

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