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Initiating a Genetics Study with African American Participants. Randye J. Semple, Ph.D. College of Physicians & Surgeons Columbia University New York, NY. Rationale . AA may have different susceptibility to Major Depressive Disorder (MDD) Lower lifetime prevalence

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Initiating a genetics study with african american participants

Initiating a Genetics Study with African American Participants

Randye J. Semple, Ph.D.

College of Physicians & Surgeons

Columbia University

New York, NY


Rationale
Rationale Participants

  • AA may have different susceptibility to Major Depressive Disorder (MDD)

    • Lower lifetime prevalence

    • May have slightly greater resilience (e.g., the 5-HTTLPR long allele)

    • Similar familial aggregation

  • No formal family studies of MDD in AA


Reduced lifetime prevalence of mdd
Reduced Lifetime Prevalence of MDD Participants

  • Odds ratio 0.63

    National Comorbidity Survey

    Kessler, et al. (1994)

  • Odds ratio 0.6

    NCS Replication Study

    Kessler, et al. (2003)


Lifetime prevalence of mdd by race gender
Lifetime Prevalence of MDD by Race Participants& Gender

National Survey of American Life, Jackson et al. 2001


Rates of mdd mdd with positive family history
Rates of MDD Participants& MDD with positive family history

* Χ2 = 8.02, p = .018 ** Χ2 = 0.3, n.s.

Weissman, et al. (unpublished data)


Genred i 1999 2003
GenRED-I (1999-2003) Participants

  • Collected one of the largest pedigree samples in genetics research

    • 680 pedigrees (927 independent ASPs)

      • But < 3% of sample is AA

  • Only publicly-funded large-scale genetic study of MDD with +FH

  • Genetic & clinical data will be available through NIMH repository


Genred ii aims
GenRED-II Aims Participants

  • Expand a repository-based clinical sample

  • Correct the under-representation of African-Americans in genetic studies

  • Identify genes that confer susceptibility to recurrent early-onset major depression (MDD-RE)


Goals 2005 2009
Goals (2005 – 2009) Participants

  • Collect DNA samples from probands with MDD-RE & +FH diagnosed by clinical interview & psychiatric records

    • 530 African American

    • 1,026 EUR-White

  • Identify one or more MDD susceptibility genes


  • Potential obstacles
    Potential obstacles Participants

    Stigma of mental health diagnoses

    Clinical presentation with somatization

    Limited access to research information

    Mistrust of medical institutions

    Problems in physician-patient relationship

    Personal circumstances

    e.g., child care demands, job flexibility, geographic proximity to research sites


    Eligibility criteria
    Eligibility criteria Participants

    • Are 21 years or older

    • Have had 2 or more MDEs

    • Have had 1 MDE by age 30

    • Have a brother, sister or parent who has had MDD-RE

    • Do not have Bipolar Disorder



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