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OBAT SUSUNAN SARAF OTONOM. FUNGSI SISTEM S. OTONOM. 1. Untuk sistem Simpatis- Parasimpatis yang bersifat ANTAGONIS Terkadang efek antara S- PS sama Saling melengkapi. PARASIMPATIS (cholinergic) Di sebut cholinergic karena S.Parasimpatis memiliki neurotransmiter ASETILKOLIN (ACH).

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fungsi sistem s otonom
FUNGSI SISTEM S. OTONOM

1. Untuk sistem Simpatis- Parasimpatis yang bersifat ANTAGONIS

  • Terkadang efek antara S- PS sama
  • Saling melengkapi
slide5

PARASIMPATIS

(cholinergic)

Di sebut cholinergic karena S.Parasimpatis memiliki neurotransmiter ASETILKOLIN (ACH)

slide6

2. SIMPATIS

(adrenergic)

Di sebut adrenergic karena S.Simpatis memiliki neurotransmiter ADRENAL dan NORADRENAL

ATAU

EPINEPRIN dan NOREPINEPRIN

pre ganglion neurotransmiter
PRE-GANGLION neurotransmiter

Parasimpatis dan Simpatis memiliki neurotransmiter yang SAMA yaitu

ACETHYLCOLINE (ACh)

post ganglion neurotransmiter
POST-GANGLION neurotransmiter

Parasimpatis ACETHYLCOLINE

SimpatisNORADRENALIN atau NOREPINEPRIN

reseptor
RESEPTOR
  • Reseptor CHOLINERGIC (PS):

Terdiri dari NICOTINIC dan MUSCARINIK

NICOTINIK terdapat di semua GANGLIA dan SKELETAL MUSCLE (otot rangka)

slide13

MUSCARINIK (M)

M1 : beberapa kelenjar

M2: Jantung

M3: Otot polos, kelenjar

Reseptor MUSKARINIK terdapat di:

Otot polos ( GI track, bronkus)

Otot Jantung ( meningkatkan detak jtg)

Kelenjar (Exocrine merangsang sekresi Kel. saliva)

Terdapat juga di OTAK

2 reseptor adrenergic
2. Reseptor ADRENERGIC
  • α1 (Post-sinap): mempengaruhi otot pembuluh darah
  • α2 (Pre-sinap): jika terstimulasi akan meningkatkan siklus AMP intrasel
  • β1 (post-sinap)
  • β2 (Post-sinap)