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VITILIGO Pharmacology IV (PHL 425)

VITILIGO Pharmacology IV (PHL 425). Dr. Abdulaziz Saeedan PhD, Pharmacology Email: a.binsaeedan@psau.edu.sa. What is vitiligo ?.

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VITILIGO Pharmacology IV (PHL 425)

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  1. VITILIGOPharmacology IV (PHL 425) Dr. Abdulaziz Saeedan PhD, Pharmacology Email: a.binsaeedan@psau.edu.sa

  2. What is vitiligo? • Vitiligo is a skin pigmentation disorder characterized by white patches surrounded by heavily pigmented borders. It occurs when melanocytes, the cells responsible for skin pigmentation, die or unable to function • Autoimmune disorder • Genetic link / blood relatives (not always) • Affects 1-2% of population irrespective of sex and race • Difficult to cure • Harmful effects

  3. Symptoms • White patches on the skin which may vary in size and shape (no fixed pattern) • These patches may appear on different parts of the body • The hair present on the affected areas some time turn white • These patches may start progression or re-pigment on their own

  4. Treatment • Long and difficult process, rarely 100% effective on individual • Always involves sunlight or ultraviolet light • Physical and chemical methods • Cosmetics • Depigmentation • Psychological counseling

  5. Chemical Treatment • Topical steroid therapy: Steroid creams may be helpful in repigmenting (returning the color to) white patches, particularly if they are applied in the initial stages of the disease. • Psoralensphotochemotherapy (PUVA): this is probably the most effective treatment for vitiligo (re-pigmentation of the white patches) • Depigmentation: Fading the rest of the skin on the body to match the areas that are already white. • Monobenzone twice a day until pigmented areas match the already-depigmented areas • Phenylalanine: This essential amino acid is the precursor for the skin pigment melanin.

  6. Physical Treatment • Tattooing (micro-pigmentation): Implanting pigment into the skin with a special surgical instrument • Autologous skin grafts:skin is removed from one area of the body and attached to another area • Autologous melanocyte transplantation: a sample of the normal pigmented skin is taken and placed it in a laboratory dish containing a special cell-culture solution to grow melanocytes. When the melanocytes in the culture solution have multiplied, they are transplanted on depigmented skin patches • Sunscreen and cosmotics

  7. Thank you

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