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LIPOPOLYSACCHARIDE (LPS)

LIPOPOLYSACCHARIDE (LPS). By Nawal M.Hijazi October-2004. Role of lipopolysaccharide in the outer membrane. - Permeability barrier - Adhernes and colonization. CHEMICAL NATURE OF LPS.

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LIPOPOLYSACCHARIDE (LPS)

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  1. LIPOPOLYSACCHARIDE (LPS) By Nawal M.Hijazi October-2004

  2. Role of lipopolysaccharide in the outer membrane • - Permeability barrier - Adhernes and colonization

  3. CHEMICAL NATURE OF LPS • Region I lipid A • Region II core antigin • Region III O polysaccharide

  4. CHEMICAL NATURE OF LPS Figure 3. Glc = glucose; GlcNac = N-acetyl- glucosamine; Gal = galactose; Hep = heptose; P = phosphate; Etn = ethanolamine; R1 and R2 = phoshoethanolamine or aminoarabinose. Ra to Re indicate incomplete forms of LPS. The Rd2 phenotype (not shown) would have only a single heptose unit. The Rc, Rd2, and Rd1 mutants lack the phosphate group attached to Hep.

  5. THE O POLYSACCHARIDE &VIRULENCE • -Smoothness • -Resistance to phagocytosis -Protection against complement

  6. LIPID A & VIRULENCE • Production of:- • Cytokin and tumer necrosing factor • Complement cascade • Activation of coagulation cascade Figure.4 Endotoxin and the pyrogenic effect .

  7. LABORATORY IDENTIFICATION OF LPS • Limulus Amoebocyte Lysat (LAL) Assay • Enzyme-linked immunoassay

  8. He who makes no mistakes, make nothing • I thank y0u kindly……………………………

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