Steroidal Anti-inflammatory Drugs (SAIDs). Hypothalamic-Pituitary Adrenal (HPA) Axis. Negative Feedback control of ACTH Production. Suppression of HPA STRESS: Overrides the neg. feedback mechanism . Adrenal cortex Produces 30 steroid hormones Major divisions include:
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Negative Feedback control
of ACTH Production.
Suppression of HPA
STRESS: Overrides the
neg. feedback mechanism.
Produces 30 steroid hormones
Major divisions include:
Adrenal Sex steroids
90% bound to plasma proteins
Of GCs; highest in
the early morning
and lowest in the
Corticosteroids control symptoms and DO NOT stop progression (cure) of the disease
Metered Dose Inhaler
Also, Dry-powder inhalers
Taken Daily, over a long period of time
SE: oropharyngeal candidiasis (Thrush), dysphonia (hoarseness), adrenal suppression, bone loss, in children, retarded growth
Reduced risk of toxicity with inhaled preparations
Mechanisms of Action:
Glucocorticoid Withdrawal: Should be performed slowly
Withdrawal syndrome: hypotension, hypoglycemia, myalgia and fatigue