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Regulation of Adipocyte Lipolysis. Catecholamines Epinephrine & Norepinephrine Beta Adrenergic Receptors Stimulate Alpha Adrenergic Receptors Inhibit Insulin Inhibitory. Catecholamines. Stimulatory B-Adrenergic Receptors Activates Stimulatory G-Protein Activates Adenylate Cyclase

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regulation of adipocyte lipolysis
Regulation of Adipocyte Lipolysis
  • Catecholamines
    • Epinephrine & Norepinephrine
      • Beta Adrenergic Receptors
        • Stimulate
      • Alpha Adrenergic Receptors
        • Inhibit
  • Insulin
    • Inhibitory
catecholamines
Catecholamines
  • Stimulatory
    • B-Adrenergic Receptors
    • Activates Stimulatory G-Protein
    • Activates Adenylate Cyclase
    • Generates cAMP
    • Activates cAMP-dependent protein kinase
    • Phosphorylates HSL & Perilipins
    • Break down triglycerides
  • Inhibitory
    • A-Adrenergic Receptors
    • Activates Inhibitory G-protein
    • Inhibits Adenylate Cyclase
slide3

Catecholamines stimulate HSL to break down triglycerides to fatty acids and glycerol

  • Fatty acids and glycerol are released into the blood and circulated to other body tissues
slide4
ATGL
  • Adipose Triglyceride Lipase
    • Enzyme that may be responsible forcatalyzing the initial steps of triglyceride hydrolysis.
    • Zimmermann et al. (2004)
      • HSL knock-out mice showed an accumulation of diglycerides, suggesting that additional lipases may be present that can hydrolyze the first ester bond of triglycerides
    • Still controversial
insulin
Insulin

Lipoprotein Lipase (LPL)

Phosphatidylinositol 3-Kinase (PI3K)

Hydrolyzes

Phosphorylates

Plasma Triglycerides

Phosphodiesterase-3

Degrades

Into

cAMP

FFA

insulin7

PI3K

Insulin

Phosphorylates

  • LPL
    • Hydrolyzes triglycerides in the blood to increase FFA levels
  • PI3K
    • Inhibits lipolysis in adipose cells
    • Mediates insulin-stimulated glucose uptake

Phosphodiestesterase-3

Degrades