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First a review…. Adopt as a perspective that: One B-cell produces one antibody Make that perspective more exacting: One B-cell produces one idiotype . Cassettes (V, J, [D],) ( aka gene segments ) “fuse” ( to make an idiotype ).

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first a review
First a review…

Adopt as a perspective that:

One B-cell produces one antibody

Make that perspective more exacting:

One B-cell produces one idiotype.

Cassettes (V, J, [D],) (aka gene segments) “fuse” (to make an idiotype).

Fusing occurs because RAG recognizes one turn/two turn signals on cassettes.

CDR3 develops through junctional flexibility (trimming) and addition of P & N nucleotides (expanding).

CDR1 and CDR2 (especially) and CDR3 become more varied because of somatic hypermutation.

first a review now with images
First a review… now with images

And, I will use images from a different source.

Remember to be critical of what “interpretative” drawings convey…

first a review still with images
First a review… still with images

RAG: what does it do? …how does it work?

first a review still with more images
First a review… still with more images

RAG: what does it do? …how does it work?

…what about P&N nucleotides?

p art iv some new stuff
PART IV (some new stuff)
  • How do immunoglobulins assemble?
  • Some immunoglobulins are in the surface membrane of immature B-cells while other immunoglobulins of the same idiotype are secreted by mature B-cells. What’s the difference?
  • Similarly, identical variable regions can be shared among different isotypes. How?
  • B-cells are diploids with two sets of genetic instructions. How does just one set get expressed?
slide9

Some immunoglobulins are in the surface membrane of immature B-cells while other immunoglobulins of the same idiotype are secreted by mature B-cells. What’s the difference?

the general scheme of b cell development
The general scheme of B-cell development
  • STEM CELL

  • pro (genitor) Bcell

  • pre Bcell

  • Ag-selected ( stimulated)- Bcell

  • Ab secreting plasma cell