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Vojtěch Kupka Brno, University of Technology, Faculty of Chemistry. HYALURONIC ACID. DISCOVERY. 1934 - Karl Meyer and his assistant John Palmer isolated new glykoaminoglycane from the vitreous humour of bovine eyes. vitreous humour – sklivec bovine – hovězí, kravský. ETYMOLOGY.

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discovery
DISCOVERY

1934 - Karl Meyer and his assistant John Palmer isolated new glykoaminoglycane from the vitreous humour of bovine eyes

vitreous humour – sklivec

bovine – hovězí, kravský

etymology
ETYMOLOGY

-hyalos (Greek for vitreous)

-uronic acid (possesses high content of uronic acid)

structure
STRUCTURE

-it consists of repeating disacharides units

D-N‑acetylglucosamine

b-D-glucuronic acid

-the units are joined with repeating beta‑1,4 and beta‑1,3 glycosidic bonds

occurence and physiological importance
OCCURENCE AND PHYSIOLOGICAL IMPORTANCE

-in the skin (about 50 % of the total hyaluronan in the body)

-the vitreous humour of the eye

-in the synovial fluid (3‑4 mg/ml)

-in the matrix around the oocyt during ovulation

(~0,5 mg/ml)

-in some situations rapid increase

(shock incidents, wound healing, septicaemia)

synovial fluid - kloubní maz

wound healing – hojení ran

septicaemia – otrava krve

slide9
USE
  • in the late fifties hyaluronan was applied for the first time to humans - as vitreous humour replacement during eye surgery

- hyaluronan improves properties of synovia and silences pain in joints

surgery – operace, chirurgie

joint - kloub

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- for healthy and fresh skin

to improve the effectiveness of local anaesthesia

to prevent tissue destruction

hyaluronates are widely used in many branches of medicine like orthopaedia, surgery, ophthalmology, oncology, dermatology, gynaecology

- may have anticancer effects and can suppress tumour progression, however, the findings are rather inconsistent

suppress – potlačovat

tumour – nádor, otok, zduření